Whiter matter abnormalities in medication-naive subjects with a single short-duration episode of major depressive disorder

被引：79

作者：

Wu, Feng ^{[2
]}

Tang, Yanqing ^{[2
]}

Xu, Ke ^{[1
]}

Kong, Lingtao ^{[2
]}

Sun, Wenge ^{[1
]}

Wang, Fei ^{[3
]}

Kong, Dongyan ^{[2
,4
]}

Li, Yanliang ^{[1
]}

Liu, Ying ^{[2
]}

机构：

[1] China Med Univ, Dept Radiol, Affiliated Hosp 1, Shenyang 110001, Liaoning, Peoples R China

[2] China Med Univ, Dept Psychiat, Affiliated Hosp 1, Shenyang 110001, Liaoning, Peoples R China

[3] Yale Univ, Sch Med, Dept Psychiat, New Haven, CT 06511 USA

[4] Quanzhou First Hosp, Dept Psychol, Quanzhou 362000, Fujian, Peoples R China

来源：

PSYCHIATRY RESEARCH-NEUROIMAGING | 2011年 / 191卷 / 01期

基金：

中国国家自然科学基金;

关键词：

Diffusion tensor imaging; Fractional anisotropy; Superior longitudinal fasciculus; LATE-LIFE DEPRESSION; DORSOLATERAL PREFRONTAL CORTEX; VOXEL-BASED MORPHOMETRY; ANTERIOR CINGULATE; COGNITIVE-CONTROL; GERIATRIC DEPRESSION; UNIPOLAR DEPRESSION; MICROSTRUCTURAL ABNORMALITIES; EXECUTIVE CONTROL; SYMPTOM SEVERITY;

D O I：

10.1016/j.pscychresns.2010.09.002

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Convergent studies have implicated white matter abnormalities in the pathophysiology of major depressive disorder (MDD). In this study, diffusion tensor imaging (DTI) was used to examine white matter abnormalities in 23 single-episode, medication-naive MDD participants versus 21 healthy control participants. Voxel-based analysis was used to investigate whole brain white matter abnormalities in the MDD group. Fractional anisotropy was significantly lower and apparent diffusion coefficient was significantly higher in the right superior longitudinal fasciculus (SLF) within the frontal lobe, right middle frontal and left parietal white matter in the MOD group compared with the healthy group. (C) 2010 Elsevier Ireland Ltd. All rights reserved.

引用

页码：80 / 83

页数：4

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