Large cell morphology, CMYC plus tumour cells, and PD-1+tumour cell/intense PD-L1+cell reactions are important prognostic factors in nodal peripheral T-cell lymphomas with T follicular helper markers

被引:2
作者
Mihashi, Yasuhito [1 ,2 ]
Kimura, Shoichi [1 ,2 ]
Iwasaki, Hiromi [3 ]
Oshiro, Yumi [4 ]
Takamatsu, Yasushi [5 ]
Kawauchi, Shigeto [6 ]
Shimajiri, Shohei [7 ]
Ishizuka, Kenji [8 ]
Takeshita, Morishige [1 ]
机构
[1] Fukuoka Univ, Fac Med, Dept Pathol, Jonan Ku, 7-45-1 Nanakuma, Fukuoka 8140180, Japan
[2] Fukuoka Univ, Fac Med, Dept Otolaryngol, Jonan Ku, 7-45-1 Nanakuma, Fukuoka 8140180, Japan
[3] Natl Hosp Org Kyushu Med Ctr, Clin Res Ctr, Dept Haematol, Chuo Ku, 1-8-1 Jigyohama, Fukuoka 8108563, Japan
[4] Matsuyama Red Cross Hosp, Dept Pathol, 1 Bunkyo Cho, Matsuyama, Ehime 7910000, Japan
[5] Fukuoka Univ, Fac Med, Dept Internal Med, Div Med Oncol Haematol & Infect Dis,Jonan Ku, 7-45-1 Nanakuma, Fukuoka 8140180, Japan
[6] Natl Hosp Org Kyushu Med Ctr, Clin Res Ctr, Dept Pathol, Chuo Ku, 1-8-1 Jigyohama, Fukuoka 8108563, Japan
[7] Univ Occupat & Environm Hlth, Dept Pathol, Nishi Ku, Kitakyushu, Fukuoka, Japan
[8] Kagoshima Univ, Fac Med, Dept Internal Med, Sakuragaoka 8-35-1, Kagoshima 8908544, Japan
关键词
AITL; CMYC; PD-1; PD-L1; Peripheral T-cell lymphoma; T follicular helper cell; MYC PROTEIN; EXPRESSION; REARRANGEMENT;
D O I
10.1186/s13000-021-01163-7
中图分类号
R36 [病理学];
学科分类号
100104 ;
摘要
Background The clinicopathological characteristics and prognostic factors in nodal peripheral T-cell lymphomas (PTCLs) with two or more T follicular helper markers (TFH+) are not adequately investigated. Methods Immunohistologically, we selected 22 patients with TFH+ lymphoma (PTCL-TFH) in 47 of PTCL-not otherwise specified (NOS), and subclassified into large and small cell groups. We compared the two groups with 39 angioimmunoblastic T-cell lymphoma (AITL) and seven follicular T-cell lymphoma (F-TCL) patients. Prognostic factors were analysed by overall survival in patients with three types of TFH+ PTCLs. Results Thirteen large cell and nine small cell PTCL-TFH patients had more than two TFH markers including programmed cell death-1 (PD-1). Large cell PTCL-TFH showed frequent CMYC expression in 10 patients (77%), and four of 11 large cell group (36%) had somatic RHOA G17V gene mutation by Sanger sequencing. Large cell PTCL-TFH patients showed significantly worse prognosis than those of the small cell group, AITL, and F-TCL (p < 0.05). In TFH+ PTCLs, CMYC+ tumour cells, and combined PD-1 ligand 1 (PD-L1) + tumour cells and intense reaction of PD-L1+ non-neoplastic cells (high PD-L1+ cell group) were significantly poor prognostic factors (p < 0.05). Combinations of CMYC+ or PD-1+ tumour cells and high PD-L1+ cell group indicated significantly poor prognosis (p < 0.01). Conclusion Large cell PTCL-TFH indicated poor prognosis in TFH+ PTCLs. These data suggested that CMYC+ tumour cells and intense PD-L1+ cell reaction influenced tumour cell progression in TFH+ PTCLs, and PD-1+ tumour cell/intense PD-L1+ cell reactions may play a role in immune evasion.
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页数:10
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