Lewis acid-catalyzed Friedel-Crafts reactions toward highly versatile, α-quaternary oxime ethers

被引：17

作者：

Schlegel, Marcel ^{[1
]}

Schneider, Christoph ^{[1
]}

机构：

[1] Univ Leipzig, Inst Organ Chem, Johannisallee 29, D-04103 Leipzig, Germany

来源：

CHEMICAL COMMUNICATIONS | 2018年 / 54卷 / 79期

关键词：

TERTIARY ALCOHOLS; DIAZONAMIDE-A; ALKYLATION; INDOLES; ESTERS;

D O I：

10.1039/c8cc06823b

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The synthesis of all-carbon-substituted, quaternary stereocenters through Lewis acid-catalyzed Friedel-Crafts alkylation of cyclic and acyclic 2-hydroxy oxime ethers proceeds under mild reaction conditions and with high yields. Moreover, the oxime ether moiety can be easily manipulated into various functional groups through subsequent modifications.

引用

页码：11124 / 11127

页数：4

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