Broadly neutralizing antibodies for HIV-1: efficacies, challenges and opportunities

被引：69

作者：

Liu, Yubin ^{[1
,2
]}

Cao, Wei ^{[1
,2
]}

Sun, Ming ^{[3
,4
]}

Li, Taisheng ^{[1
,2
,5
,6
]}

机构：

[1] Peking Union Med Coll, Peking Union Med Coll Hosp, Dept Infect Dis, Beijing, Peoples R China

[2] Chinese Acad Med Sci, Beijing, Peoples R China

[3] Chinese Acad Med Sci, Inst Med Biol, Kunming, Yunnan, Peoples R China

[4] Yunnan Key Lab Vaccine Res & Dev Severe Infect Di, Kunming, Yunnan, Peoples R China

[5] Chinese Acad Med Sci, Clin Immunol Ctr, Beijing, Peoples R China

[6] Tsinghua Univ, Med Coll, Beijing, Peoples R China

来源：

EMERGING MICROBES & INFECTIONS | 2020年 / 9卷 / 01期

基金：

中国国家自然科学基金;

关键词：

HIV-1; broadly neutralizing antibodies (bNAbs); efficacies; challenges; opportunities; IMMUNODEFICIENCY-VIRUS TYPE-1; MONOCLONAL-ANTIBODIES; T-CELLS; THERAPY; INFECTION; SPREAD; PROTECTION; RESISTANT; IDENTIFICATION; REPLICATION;

D O I：

10.1080/22221751.2020.1713707

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Combination antiretroviral therapy (cART) is effective but not curative, and no successful vaccine is currently available for human immunodeficiency virus-1 (HIV-1). Broadly neutralizing antibodies (bNAbs) provide a new approach to HIV-1 prevention and treatment, and these promising candidates advancing into clinical trials have shown certain efficacies in infected individuals. In addition, bNAbs have the potential to kill HIV-1-infected cells and to affect the course of HIV-1 infection by directly engaging host immunity. Nonetheless, challenges accompany the use of bNAbs, including transient suppression of viraemia, frequent emergence of resistant viruses in rebound viraemia, suboptimal efficacy in virus cell-to-cell transmission, and unclear effects on the cell-associated HIV-1 reservoir. In this review, we discuss opportunities and potential strategies to address current challenges to promote the future use of immunotherapy regimens.

引用

页码：194 / 206

页数：13

共 88 条

[1] Cell-Cell Transmission Enables HIV-1 to Evade Inhibition by Potent CD4bs Directed Antibodies [J].

Abela, Irene A. ;

Berlinger, Livia ;

Schanz, Merle ;

Reynell, Lucy ;

Guenthard, Huldrych F. ;

Rusert, Peter ;

Trkola, Alexandra .

PLOS PATHOGENS, 2012, 8 (04)

[2] Systems serology for evaluation of HIV vaccine trials [J].

Ackerman, Margaret E. ;

Barouch, Dan H. ;

Alter, Galit .

IMMUNOLOGICAL REVIEWS, 2017, 275 (01) :262-270

[3] Unique Features of HIV-1 Spread through T Cell Virological Synapses [J].

Alvarez, Raymond A. ;

Barria, Maria Ines ;

Chen, Benjamin K. .

PLOS PATHOGENS, 2014, 10 (12)

[4]

[Anonymous], RAND DOUBL BLIND PLA

[5] Multispecific anti-HIV duoCAR-T cells display broad in vitro antiviral activity and potent in vivo elimination of HIV-infected cells in a humanized mouse model [J].

Anthony-Gonda, Kim ;

Bardhi, Ariola ;

Ray, Alex ;

Flerin, Nina ;

Li, Mengyan ;

Chen, Weizao ;

Ochsenbauer, Christina ;

Kappes, John C. ;

Krueger, Winfried ;

Worden, Andrew ;

Schneider, Dina ;

Zhu, Zhongyu ;

Orentas, Rimas ;

Dimitrov, Dimiter S. ;

Goldstein, Harris ;

Dropulic, Boro .

SCIENCE TRANSLATIONAL MEDICINE, 2019, 11 (504)

[6] Bispecific Antibodies Targeting Different Epitopes on the HIV-1 Envelope Exhibit Broad and Potent Neutralization [J].

Asokan, M. ;

Rudicell, R. S. ;

Louder, M. ;

McKee, K. ;

O'Dell, S. ;

Stewart-Jones, G. ;

Wang, K. ;

Xu, L. ;

Chen, X. ;

Choe, M. ;

Chuang, G. ;

Georgiev, I. S. ;

Joyce, M. G. ;

Kirys, T. ;

Ko, S. ;

Pegu, A. ;

Shi, W. ;

Todd, J. P. ;

Yang, Z. ;

Bailer, R. T. ;

Rao, S. ;

Kwong, P. D. ;

Nabel, G. J. ;

Mascola, J. R. .

JOURNAL OF VIROLOGY, 2015, 89 (24) :12501-12512

[7] Therapeutic Efficacy of Vectored PGT121 Gene Delivery in HIV-1-Infected Humanized Mice [J].

Badamchi-Zadeh, Alexander ;

Tartaglia, Lawrence J. ;

Abbink, Peter ;

Bricault, Christine A. ;

Liu, Po-Ting ;

Boyd, Michael ;

Kirilova, Marinela ;

Mercado, Noe B. ;

Nanayakkara, Ovini S. ;

Vrbanac, Vladimir D. ;

Tager, Andrew M. ;

Larocca, Rafael A. ;

Seaman, Michael S. ;

Barouch, Dan H. .

JOURNAL OF VIROLOGY, 2018, 92 (07)

[8] Antibody-based protection against HIV infection by vectored immunoprophylaxis [J].

Balazs, Alejandro B. ;

Chen, Joyce ;

Hong, Christin M. ;

Rao, Dinesh S. ;

Yang, Lili ;

Baltimore, David .

NATURE, 2012, 481 (7379) :81-U88

[9] Effect of HIV Antibody VRC01 on Viral Rebound after Treatment Interruption [J].

Bar, K. J. ;

Sneller, M. C. ;

Harrison, L. J. ;

Justement, J. S. ;

Overton, E. T. ;

Petrone, M. E. ;

Salantes, D. B. ;

Seamon, C. A. ;

Scheinfeld, B. ;

Kwan, R. W. ;

Learn, G. H. ;

Proschan, M. A. ;

Kreider, E. F. ;

Blazkova, J. ;

Bardsley, M. ;

Refsland, E. W. ;

Messer, M. ;

Clarridge, K. E. ;

Tustin, N. B. ;

Madden, P. J. ;

Oden, K. S. ;

O'Dell, S. J. ;

Jarocki, B. ;

Shiakolas, A. R. ;

Tressler, R. L. ;

Doria-Rose, N. A. ;

Bailer, R. T. ;

Ledgerwood, J. E. ;

Capparelli, E. V. ;

Lynch, R. M. ;

Graham, B. S. ;

Moir, S. ;

Koup, R. A. ;

Mascola, J. R. ;

Hoxie, J. A. ;

Fauci, A. S. ;

Tebas, P. ;

Chun, T-W .

NEW ENGLAND JOURNAL OF MEDICINE, 2016, 375 (21) :2037-2050

[10] Safety and antiviral activity of combination HIV-1 broadly neutralizing antibodies in viremic individuals [J].

Bar-On, Yotam ;

Gruell, Henning ;

Schoofs, Till ;

Pai, Joy A. ;

Nogueira, Lilian ;

Butler, Allison L. ;

Millard, Katrina ;

Lehmann, Clara ;

Suarez, Isabelle ;

Oliveira, Thiago Y. ;

Karagounis, Theodora ;

Cohen, Yehuda Z. ;

Wyen, Christoph ;

Scholten, Stefan ;

Handl, Lisa ;

Belblidia, Shiraz ;

Dizon, Juan P. ;

Vehreschild, Joerg J. ;

Witmer-Pack, Maggi ;

Shimeliovich, Irina ;

Jain, Kanika ;

Fiddike, Kerstin ;

Seaton, Kelly E. ;

Yates, Nicole L. ;

Horowitz, Jill ;

Gulick, Roy M. ;

Pfeifer, Nico ;

Tomaras, Georgia D. ;

Seaman, Michael S. ;

Faetkenheuer, Gerd ;

Caskey, Marina ;

Klein, Florian ;

Nussenzweig, Michel C. .

NATURE MEDICINE, 2018, 24 (11) :1701-+

← 1 2 3 4 5 6 7 8 9 →