Cordyceps militaris: An Overview of Its Chemical Constituents in Relation to Biological Activity

被引：83
作者：
Jedrejko, Karol Jerzy [1 ]
Lazur, Jan [1 ]
Muszynska, Bozena [1 ]
机构：
[1] Jagiellonian Univ Med Coll, Dept Pharmaceut Bot, Fac Pharm, 9 Medyczna Str, PL-30688 Krakow, Poland
来源：
FOODS | 2021年 / 10卷 / 11期
关键词：
Cordyceps militaris; bioactive compounds; biological activities; cordycepin; ergothioneine; polysaccharides; SUBMERGED CULTURED MYCELIA; GAMMA-AMINOBUTYRIC-ACID; HIGH-FAT DIET; STRUCTURAL-CHARACTERIZATION; FRUITING BODIES; ANTIOXIDANT ACTIVITY; IMMUNOSTIMULATORY ACTIVITY; INFLAMMATORY MEDIATORS; MEDICINAL VALUE; TUMOR-GROWTH;
D O I：
10.3390/foods10112634
中图分类号：
TS2 [食品工业];
学科分类号：
0832 ;
摘要：
Cordyceps spp. mushrooms have a long tradition of use as a natural raw material in Asian ethnomedicine because of their adaptogenic, tonic effects and their ability to reduce fatigue and stimulate the immune system in humans. This review aims to present the chemical composition and medicinal properties of Cordyceps militaris fruiting bodies and mycelium, as well as mycelium from in vitro cultures. The analytical results of the composition of C. militaris grown in culture media show the bioactive components such as cordycepin, polysaccharides, gamma-aminobutyric acid (GABA), ergothioneine and others described in the review. To summarize, based on the presence of several bioactive compounds that contribute to biological activity, C. militaris mushrooms definitely deserve to be considered as functional foods and also have great potential for medicinal use. Recent scientific reports indicate the potential of cordycepin in antiviral activity, particularly against COVID-19.
引用
收藏
页数：24
相关论文
共 161 条
[11]  
[蔡鸿彦 Cai Hongyan], 2004, [中国新药杂志, Chinese Journal New Drugs], V13, P171
[12]   Identification and quantification of phenolic acid compounds of twenty-six mushrooms by HPLC-DAD [J].
Cayan, Fatih ;
Deveci, Ebru ;
Tel-Cayan, Gulsen ;
Duru, Mehmet Emin .
JOURNAL OF FOOD MEASUREMENT AND CHARACTERIZATION, 2020, 14 (03) :1690-1698
[13]   Chemical Composition and Medicinal Value of Fruiting Bodies and Submerged Cultured Mycelia of Caterpillar Medicinal Fungus Cordyceps militaris CBS-132098 (Ascomycetes) [J].
Chan, Jannie Siew Lee ;
Barseghyan, Gayane S. ;
Asatiani, Mikheil D. ;
Wasser, Solomon P. .
INTERNATIONAL JOURNAL OF MEDICINAL MUSHROOMS, 2015, 17 (07) :649-659
[14]   Administration of Pure Ergothioneine to Healthy Human Subjects: Uptake, Metabolism, and Effects on Biomarkers of Oxidative Damage and Inflammation [J].
Cheah, Irwin K. ;
Tang, Richard M. Y. ;
Yew, Terry S. Z. ;
Lim, Keith H. C. ;
Halliwell, Barry .
ANTIOXIDANTS & REDOX SIGNALING, 2017, 26 (05) :193-206
[15]   Ergothioneine levels in an elderly population decrease with age and incidence of cognitive decline; a risk factor for neurodegeneration? [J].
Cheah, Irwin K. ;
Feng, Lei ;
Tang, Richard M. Y. ;
Lim, Keith H. C. ;
Halliwell, Barry .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2016, 478 (01) :162-167
[16]   Bioactive Metabolites and Potential Mycotoxins Produced by Cordyceps Fungi: A Review of Safety [J].
Chen, Bo ;
Sun, Yanlei ;
Luo, Feifei ;
Wang, Chengshu .
TOXINS, 2020, 12 (06)
[17]   Ultrahigh pressure extraction of polysaccharides from Cordyceps militaris and evaluation of antioxidant activity [J].
Chen, Ruizhan ;
Jin, Chenguang ;
Li, Haiping ;
Liu, Zhiqiang ;
Lu, Juan ;
Li, Shizhe ;
Yang, Simin .
SEPARATION AND PURIFICATION TECHNOLOGY, 2014, 134 :90-99
[18]   Contents of lovastatin, γ-aminobutyric acid and ergothioneine in mushroom fruiting bodies and mycelia [J].
Chen, Shin-Yu ;
Ho, Kung-Jui ;
Hsieh, Yun-Jung ;
Wang, Li-Ting ;
Mau, Jeng-Leun .
LWT-FOOD SCIENCE AND TECHNOLOGY, 2012, 47 (02) :274-278
[19]   Structural analysis and antioxidant activities of polysaccharides from cultured Cordyceps militaris [J].
Chen, Xiaoli ;
Wu, Guanghong ;
Huang, Zhuolie .
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2013, 58 :18-22
[20]  
Cheong PCH, 2018, FUNG BIOL-US, P287, DOI 10.1007/978-3-030-02622-6_14
12345678910