Outgrowth Endothelial Cells: Sources, Characteristics and Potential Applications in Tissue Engineering and Regenerative Medicine

被引:39
作者
Fuchs, Sabine [1 ]
Dohle, Eva [1 ]
Kolbe, Marlen [1 ]
Kirkpatrick, Charles James [1 ]
机构
[1] Univ Med Johannes Gutenberg Univ, Inst Pathol, Mainz, Germany
来源
BIOREACTOR SYSTEMS FOR TISSUE ENGINEERING II: STRATEGIES FOR THE EXPANISON AND DIRECTED DIFFERENTIATION OF STEM CELLS | 2010年 / 123卷
关键词
Bone tissue engineering; Co-culture models; Endothelial progenitor cells; Vascularization; HUMAN PERIPHERAL-BLOOD; MESENCHYMAL STEM-CELLS; PROGENITOR CELLS; GROWTH-FACTOR; IN-VITRO; HUMAN OSTEOPROGENITORS; GENE-EXPRESSION; SONIC HEDGEHOG; CORD BLOOD; DIFFERENTIATION;
D O I
10.1007/10_2009_65
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
Endothelial progenitor cells from peripheral blood or cord blood are attracting increasing interest as a potential cell source for cellular therapies aiming to enhance the neovascularization of tissue engineered constructs or ischemic tissues. The present review focus on a specific population contained in endothelial progenitor cell cultures designated as outgrowth endothelial cells (OEC) or endothelial colony forming cells from peripheral blood or cord blood. Special attention will be paid to what is currently known in terms of the origin and the cell biological or functional characteristics of OEC. Furthermore, we will discuss current concepts, how OEC might be integrated in complex tissue engineered constructs based on biomaterial or co-cultures, with special emphasis on their potential application in bone tissue engineering and related vascularization strategies.
引用
收藏
页码:201 / 217
页数:17
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