Genetic architecture of human pain perception

被引：147

作者：

Diatchenko, Luda ^{[1
]}

Nackley, Andrea G. ^{[1
]}

Tchivileva, Inna E. ^{[1
]}

Shabalina, Svetlana A. ^{[2
]}

Maixner, William ^{[1
]}

机构：

[1] Univ N Carolina, Ctr Neurosensory Disorders, Chapel Hill, NC 27599 USA

[2] NIH, Natl Ctr Biotechnol Informat, Bethesda, MD 20894 USA

来源：

TRENDS IN GENETICS | 2007年 / 23卷 / 12期

关键词：

D O I：

10.1016/j.tig.2007.09.004

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Pain is emotionally detrimental and consciously avoided; however, it is absolutely crucial for our survival. Pain perception is one of the most complicated measurable traits because it is an aggregate of several phenotypes associated with peripheral and central nervous system dynamics, stress responsiveness and inflammatory state. As a complex trait, it is expected to have a pollygenic nature shaped by environmental pressures. Here we discuss what is known about these contributing genetic variants, including recent discoveries that show a crucial role of voltage-gated sodium channel Nav1.7 in pain perception and how we can advance our understanding of the pain genetic network. We propose how both rare deleterious genetic variants and common genetic polymorphisms are mediators of human pain perception and clinical pain phenotypes.

引用

页码：605 / 613

页数：9

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