Association of Gut Microbiota With Intestinal Ischemia/Reperfusion Injury

被引：19

作者：

Chen, Jingyi ^{[1
]}

Wang, Yu ^{[1
]}

Shi, Yongxia ^{[2
]}

Liu, Yongpan ^{[1
]}

Wu, Chengyi ^{[1
]}

Luo, Yanrong ^{[3
]}

机构：

[1] Hubei Univ Med, Taihe Hosp, Dept Anesthesiol, Shiyan, Peoples R China

[2] Hubei Univ Med, Taihe Hosp, Dept Surg Nursing, Shiyan, Peoples R China

[3] Shiyan Hosp Integrated Tradit & Western Med, Phys Examinat Ctr, Shiyan, Peoples R China

来源：

FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY | 2022年 / 12卷

关键词：

intestinal microbiota; metabolites; intestinal ischemia reperfusion; intestinal dysbiosis; biomarkers; BACTERIAL TRANSLOCATION; ISCHEMIA; METABOLITES; AXIS; MICE;

D O I：

10.3389/fcimb.2022.962782

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Intestinal ischemia/reperfusion (II/R) is a common acute and critical condition in clinical practice with a high mortality rate. However, there is still a lack of effective prevention and treatment measures for II/R injury. The role of the gut microbiota in II/R has attracted widespread attention. Recent evidence has demonstrated that the gut microbiota plays a pivotal role in the occurrence, development, and prognosis of II/R. Therefore, maintaining the homeostasis of gut microbiota and its metabolites may be a potential strategy for the treatment of II/R. This review focuses on the importance of crosstalk between the gastrointestinal ecosystem and II/R to highlight II/R-induced gut microbiota signatures and potential applications of microbial-based therapies in II/R. This will also provide potentially effective biomarkers for the prediction, diagnosis and treatment of II/R.

引用

页数：6

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