Ferulic acid: A review of its pharmacology, pharmacokinetics and derivatives

被引：368

作者：

Li, Dan ^{[1
]}

Rui, Yi-Xin ^{[1
]}

Guo, Shi-Duo ^{[1
]}

Luan, Fei ^{[1
]}

Liu, Rong ^{[1
]}

Zeng, Nan ^{[1
]}

机构：

[1] Chengdu Univ Tradit Chinese Med, Key Lab Breeding Base Systemat Res & Utilizat Chi, Chengdu 611137, Peoples R China

来源：

LIFE SCIENCES | 2021年 / 284卷

关键词：

Ferulic acid; Pharmacological effects; Toxicity; Pharmacokinetics; Derivatives; NF-KAPPA-B; OXIDATIVE STRESS; FREE-RADICALS; MATRIX METALLOPROTEINASES; NUCLEAR TRANSLOCATION; ANTIOXIDANT THERAPY; CELL PROLIFERATION; ENDOTHELIAL-CELLS; CANCER CELLS; RAT MODEL;

D O I：

10.1016/j.lfs.2021.119921

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Ferulic acid, a kind of phenolic substance widely existing in plants, is an important active component of many traditional Chinese medicines. So far, it has been proved that ferulic acid has a variety of biological activities, especially in oxidative stress, inflammation, vascular endothelial injury, fibrosis, apoptosis and platelet aggregation. Many studies have shown that ferulic acid can inhibit PI3K/AKT pathway, the production of ROS and the activity of aldose reductase. The anti-inflammatory effect of ferulic acid is mainly related to the levels of PPAR gamma, CAM and NF-K B and p38 MAPK signaling pathways. Ferulic acid not only protects vascular endothelium by ERK1/2 and NO/ET-1 signal, but also plays an anti-fibrosis role by TGF-13/Smad and MMPs/TIMPs system. Moreover, ferulic acid has ant-apoptotic and anti-platelet effects. In addition to the pharmacological effects of ferulic acid, its pharmacokinetics and derivatives were also discussed in this paper. This review provides the latest summary of the latest research on ferulic acid.

引用

页数：13

共 148 条

[1] Ferulic Acid Improves Cardiovascular and Kidney Structure and Function in Hypertensive Rats [J].

Alam, Md Ashraful ;

Sernia, Conrad ;

Brown, Lindsay .

JOURNAL OF CARDIOVASCULAR PHARMACOLOGY, 2013, 61 (03) :240-249

[2] Ferulic acid ameliorates the progression of pulmonary fibrosis via inhibition of TGF-β/smad signalling [J].

Ali, Syed Afroz ;

Saifi, Mohd Aslam ;

Pulivendala, Gauthami ;

Godugu, Chandraiah ;

Talla, Venu .

FOOD AND CHEMICAL TOXICOLOGY, 2021, 149

[3] Antioxidant Therapy in Alzheimer's Disease: Theory and Practice [J].

Aliev, Gjumrakch ;

Obrenovich, Mark E. ;

Reddy, V. Prakash ;

Shenk, Justin C. ;

Moreira, Paula I. ;

Nunomura, Akihiko ;

Zhu, Xiongwei ;

Smith, Mark A. ;

Perry, George .

MINI-REVIEWS IN MEDICINAL CHEMISTRY, 2008, 8 (13) :1395-1406

[4] Inhibition behaviours of some phenolic acids on rat kidney aldose reductase enzyme: an in vitro study [J].

Alim, Zuhal ;

Kilinc, Namik ;

Sengul, Bulent ;

Beydemir, Sukru .

JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, 2017, 32 (01) :277-284

[5]

Asano T, 2017, INT J MOL SCI, V18, DOI [10.3390/ijms180305, 10.3390/ijms18030550]

[6] A Methanol Extract of Adansonia digitata L. Leaves Inhibits Pro-Inflammatory iNOS Possibly via the Inhibition of NF-κB Activation [J].

Ayele, Yihunie ;

Kim, Jung-Ah ;

Park, Eunhee ;

Kim, Ye-Jung ;

Retta, Negussie ;

Dessie, Gulelat ;

Rhee, Sang-Ki ;

Koh, Kwangoh ;

Nam, Kung-Woo ;

Kim, Hee Seon .

BIOMOLECULES & THERAPEUTICS, 2013, 21 (02) :146-152

[7] HEME OXYGENASES IN CARDIOVASCULAR HEALTH AND DISEASE [J].

Ayer, Anita ;

Zarjou, Abolfazl ;

Agarwal, Anupam ;

Stocker, Roland .

PHYSIOLOGICAL REVIEWS, 2016, 96 (04) :1449-1508

[8] Aldose reductase inhibitors zopolrestat and ferulic acid alleviate hypertension associated with diabetes: effect on vascular reactivity [J].

Badawy, Dina ;

El-Bassossy, Hany M. ;

Fahmy, Ahmed ;

Azhar, Ahmad .

CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY, 2013, 91 (02) :101-107

[9]

Baeza G, 2017, FOOD FUNCT, V8, P1333, DOI [10.1039/C6FO01404F, 10.1039/c6fo01404f]

[10] Red Ginseng Marc Oil Inhibits iNOS and COX-2 via NFκB and p38 Pathways in LPS-Stimulated RAW 264.7 Macrophages [J].

Bak, Min-Ji ;

Hong, Soon-Gi ;

Lee, Jong-Won ;

Jeong, Woo-Sik .

MOLECULES, 2012, 17 (12) :13769-13786

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