Scrutinizing the Micellization Behaviour of 14-2-14 Gemini Surfactant and Tetradecyltrimethylammonium Bromide in Aqueous Solutions of Betaine Hydrochloride Drug

In the present work, we investigated the effect of drug Betaine Hydrochloride (Betaine HCl) on the aggregation behavior of ethylene-1, 2-bis (N, N-dimethyl-N-tetradecylammonium bromide) (14-2-14) and tetradecyltrimethylammonium bromide (TTAB) by employing electrical conductivity and FT-IR spectroscopic techniques. Initially, synthesis of 14-2-14 is carried out in laboratory followed by determination of critical micelle concentration (CMC) through electrical conductivity measurements at temperatures 293.15 K, 298.15 K, 303.15 K, 308.15 K in absence and presence of Betaine HCl at concentrations 0.10 mmol/kg, 0.15 mmol/kg and 0.25 mmol/kg. The decrement in CMC value is observed with increasing concentrations of Betaine HCl as well as with decreasing temperatures. Several thermodynamic parameters such as the standard enthalpy of micellization (Delta H-m(0)), the standard entropy of micellization (Delta S-m(0)) and the standard Gibbs energy of micellization (Delta G(m)(0)), etc. have been evaluated using values of CMC for various concentrations of Betaine HCl at different temperatures. The alterations instigated in respective have been recognized by FT-IR spectroscopic analysis, which signifies the variations produced by the drug on the aggregation of the surfactants (14-2-14 and TTAB) in aqueous media. (C) 2021 Elsevier B.V. All rights reserved.