A Comprehensive Overview of the Synthesis of Tetrahydrocarbazoles and its Biological Properties

被引：10

作者：

Chakroborty, Subhendu ^{[1
]}

Panda, Pravati ^{[2
]}

机构：

[1] Auro Univ, Sch Sci, Surat 394510, Gujrat, India

[2] Rama Devi Womens Univ, Dept Chem, Bhubaneswar 751004, Odisha, India

来源：

MINI-REVIEWS IN ORGANIC CHEMISTRY | 2021年 / 18卷 / 06期

关键词：

Natural indole; organocatalyzed reactions; protein kinase inhibitor; tetrahydrocarbazoles; TfOH catalyzed reactions; tumor growth inhibitor; ORGANOCATALYTIC ASYMMETRIC-SYNTHESIS; DIELS-ALDER REACTION; CATALYZED SYNTHESIS; POTENT ACTIVITY; CYCLOADDITION; 2-VINYLINDOLES; DERIVATIVES; CYCLIZATION; INDOLES; ROUTE;

D O I：

10.2174/1570193X17999200820163532

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Tetrahydrocarbazoles (THC) is a privileged structural scaffold containing natural indole as the central moiety. This extraordinary skeleton features in a plethora of naturally occurring pharma-cological compounds and alkaloids exhibiting a significant inhibitory activity such as antibacterial, protein kinase inhibitor, and tumor growth inhibitor, etc. Due to its versatile biological properties, it always gains considerable attention among the scientific community. The main objective of this re-view is to make a comprehensive reference work on the synthesis and biological properties of THCs, thus targeting a broad audience on the assessment of various catalysts along with their reaction con-dition, mechanism of action, and yield, which are categorized into three groups: 1) organocatalyzed reactions; 2) TfOH catalyzed reactions; 3) metal-catalyzed reactions and 4) miscellaneous.

引用

页码：709 / 718

页数：10

共 44 条

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