Decreased amygdala-insula resting state connectivity in behaviorally and emotionally dysregulated youth

被引：52

作者：

Bebko, Genna ^{[1
]}

Bertocci, Michele ^{[1
]}

Chase, Henry ^{[1
]}

Dwojak, Amanda ^{[1
]}

Bonar, Lisa ^{[1
]}

Almeida, Jorge ^{[1
]}

Perlman, Susan Beth ^{[1
]}

Versace, Amelia ^{[1
]}

Schirda, Claudiu ^{[1
]}

Travis, Michael ^{[1
]}

Gill, Mary Kay ^{[1
]}

Demeter, Christine ^{[2
]}

Diwadkar, Vaibhav ^{[3
]}

Sunshine, Jeffrey ^{[2
]}

Holland, Scott ^{[4
]}

Kowatch, Robert ^{[5
]}

Birmaher, Boris ^{[1
]}

Axelson, David ^{[5
]}

Horwitz, Sarah ^{[6
]}

Frazier, Thomas ^{[7
]}

Arnold, Lawrence Eugene ^{[5
]}

Fristad, Mary ^{[5
]}

Youngstrom, Eric ^{[8
]}

Findling, Robert ^{[2
,9
]}

Phillips, Mary Louise ^{[1
]}

机构：

[1] Univ Pittsburgh, Western Psychiat Inst & Clin, Dept Psychiat, Med Ctr, Pittsburgh, PA 15213 USA

[2] Case Western Reserve Univ, Univ Hosp, Case Med Ctr, Cleveland, OH 44106 USA

[3] Wayne State Univ, Dept Psychiat & Behav Neurosci, Detroit, MI 48207 USA

[4] Univ Cincinnati, Cincinnati Childrens Hosp Med Ctr, Cincinnati, OH USA

[5] Ohio State Univ, Dept Psychiat, Columbus, OH 43210 USA

[6] NYU, Sch Med, Dept Child & Adolescent Psychiat, New York, NY USA

[7] Cleveland Clin, Inst Pediat, Cleveland, OH 44106 USA

[8] Univ N Carolina, Dept Psychol, Chapel Hill, NC USA

[9] Johns Hopkins Univ, Dept Psychiat, Baltimore, MD USA

来源：

PSYCHIATRY RESEARCH-NEUROIMAGING | 2015年 / 231卷 / 01期

关键词：

IMRI; Amygdala; Insula; RDoC; Adolescents; PEDIATRIC BIPOLAR DISORDER; DEFAULT-MODE NETWORK; FUNCTIONAL CONNECTIVITY; LONGITUDINAL ASSESSMENT; ANTERIOR CINGULATE; PREFRONTAL CORTEX; CHILDREN; MANIA; CIRCUITRY; SCALE;

D O I：

10.1016/j.pscychresns.2014.10.015

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The Research Domain Criteria (RDoC) adopts a dimensional approach for examining pathophysiological processes underlying categorically defined psychiatric diagnoses. We used this framework to examine relationships among symptom dimensions, diagnostic categories, and resting state connectivity in behaviorally and emotionally dysregulated youth selected from the Longitudinal Assessment of Manic Symptoms study (n=42) and healthy control youth (n=18). Region of interest analyses examined relationships among resting state connectivity, symptom dimensions (behavioral and emotional dysregulation measured with the Parent General Behavior Inventory-10 Item Mania Scale [PGBI-10M]; dimensional severity measures of mania, depression, anxiety), and diagnostic categories (Bipolar Spectrum Disorders, Attention Deficit Hyperactivity Disorder, Anxiety Disorders, and Disruptive Behavior Disorders). After adjusting for demographic variables, two dimensional measures showed significant inverse relationships with resting state connectivity, regardless of diagnosis: 1) PGBI-10M with amygdala-left posterior insula/bilateral putamen: and 2) depressive symptoms with amygdala-right posterior insula connectivity. Diagnostic categories showed no significant relationships with resting state connectivity. Resting state connectivity between amygdala and posterior insula decreased with increasing severity of behavioral and emotional dysregulation and depression; this suggests an intrinsic functional uncoupling of key neural regions supporting emotion processing and regulation. These findings support the RDoC dimensional approach for characterizing pathophysiologic processes that cut across different psychiatric disorders. (C) 2014 Elsevier Ireland Ltd. All rights reserved.

引用

页码：77 / 86

页数：10

共 59 条

[1] Increased amygdala activation during mania: A functional magnetic resonance imaging study [J].