Helminth extracellular vesicles: Interactions with the host immune system

被引：70

作者：

Drurey, Claire ^{[1
]}

Maizels, Rick M. ^{[1
]}

机构：

[1] Univ Glasgow, Inst Infect Immun & Inflammat, Wellcome Ctr Integrat Parasitol, 120 Univ Pl, Glasgow G12 8TA, Lanark, Scotland

来源：

MOLECULAR IMMUNOLOGY | 2021年 / 137卷

基金：

英国惠康基金;

关键词：

Helminths; Immunomodulation; Vaccines; SCHISTOSOMA-MANSONI; BIOGENESIS PATHWAYS; PARASITIC NEMATODE; SECRETORY PRODUCTS; INFECTION; REVEALS; GLYCAN; ROLES; VACCINATION; ACTIVATION;

D O I：

10.1016/j.molimm.2021.06.017

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

As long-lived parasites, helminths depend upon immunomodulation of their hosts for survival. The release of excretory-secretory (ES) products, including proteins, lipids and RNAs is how successful host manipulation is achieved. It has recently been discovered that the ES products of helminths contain extracellular vesicles (EVs), with every species investigated found to secrete these lipid-bound structures. EVs are perfect for packaging and delivering immune modulators to target cell types. This review outlines the research carried out on helminth EVs and their constituents thus far, as well as their interaction with components of the mammalian immune system. We discuss how targeting EVs will aid treatment of helminth infection and consider how EVs and their immunomodulatory cargo could be used as therapeutics as we progress through this exciting era.

引用

页码：124 / 133

页数：10

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