Combined cardiopulmonary assessments with implantable telemetry device in conscious freely moving cynomolgus monkeys

被引:14
作者
Authier, S. [1 ,2 ]
Haefner, Paul [3 ]
Fournier, S. [1 ]
Troncy, E. [2 ]
Moon, L. B. [3 ]
机构
[1] LAB Res Inc, Laval, PQ H7V 4B3, Canada
[2] Univ Montreal, Fac Med Vet, GREPAQ, Dept Vet Biomed, St Hyacinthe, PQ J2S 7C6, Canada
[3] Data Sci Int, St Paul, MN 55112 USA
关键词
Respiratory safety pharmacology; Cynomolgus monkeys; Impedance; Tidal volume; Respiratory rate; Minute volume; Telemetry; ICH S7A guideline; CARDIOVASCULAR MONITORING-SYSTEM; REGULATORY SAFETY PHARMACOLOGY; IMPEDANCE MINUTE VENTILATION; PACEMAKER; VALIDATION; SENSOR;
D O I
10.1016/j.vascn.2010.05.014
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Female cynomolgus monkeys were surgically implanted with telemetry transmitters recording ECG (DII), arterial pressure, physical activity, body temperature, and tidal volume. Respiratory rate (RR) and tidal volume (TV) were monitored simultaneously with the telemetry transmitter using impedance. Impedance-based monitoring of RR and TV by telemetry correlated with controlled TV and with pneumotachometer (>98%) in restrained animals. Control drugs with cardiovascular and respiratory effects, including saline, medetomidine (0.01, 0.02 and 0.04 mg/kg) and cocaine (0.5, 1.0 and 1.5 mg/kg) were administered intravenously. An averaging epoch of 5 min was used for analysis of respiratory data. Medetomidine induced significant respiratory depression with decrease in RR and TV in freely moving animals while cocaine increased TV, RR and minute ventilation (MV) with concomitant increase in heart rate when compared with time matched values from saline-treated animals. The onset, duration and magnitude of cardiovascular and respiratory changes were correlated. This highlights the dependency of the cardiovascular and respiratory systems. The use of cardiopulmonary monitoring can allow continuous monitoring including during night time when variability of respiratory parameters is lower. Monitoring of cardiovascular and respiratory parameters in the same animals could also help to decrease the number of animals used in research. (C) 2010 Elsevier Inc. All rights reserved.
引用
收藏
页码:6 / 11
页数:6
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