Microfluidic Manipulation of Core/Shell Nanoparticles for Oral Delivery of Chemotherapeutics: A New Treatment Approach for Colorectal Cancer

被引：70

作者：

Hasani-Sadrabadi, Mohammad Mahdi ^{[1
,2
]}

Taranejoo, Shahrouz ^{[3
,4
]}

Dashtimoghadam, Erfan ^{[5
]}

Bahlakeh, Ghasem ^{[6
]}

Majedi, Fatemeh Sadat ^{[7
]}

VanDersarl, Jules John ^{[8
,9
]}

Janmaleki, Mohsen ^{[10
]}

Sharifi, Fatemeh ^{[11
]}

Bertsch, Arnaud ^{[8
,9
]}

Hourigan, Kerry ^{[3
,4
]}

Tayebi, Lobat ^{[5
,12
]}

Renaud, Philippe ^{[8
,9
]}

Jacob, Karl I. ^{[1
,2
]}

机构：

[1] Georgia Inst Technol, Parker H Petit Inst Bioengn & Biosci, GW Woodruff Sch Mech Engn, Atlanta, GA 30332 USA

[2] Georgia Inst Technol, Sch Mat Sci & Engn, Atlanta, GA 30332 USA

[3] Monash Univ, Dept Chem Engn, Melbourne, Vic 3168, Australia

[4] Monash Univ, Fac Engn, Dept Mech & Aerosp Engn, Lab Biomed Engn Fluids,Lab Aeronaut & Ind Res, Melbourne, Vic 3168, Australia

[5] Marquette Univ, Sch Dent, Dept Dev Sci, Milwaukee, WI 53201 USA

[6] Amirkabir Univ Technol, Dept Chem Engn, Tehran 4941715344, Iran

[7] Univ Calif Los Angeles, Dept Bioengn, Los Angeles, CA 90095 USA

[8] Ecole Polytech Fed Lausanne, Lab Microsyst LMIS4, Inst Microengn, CH-1015 Lausanne, Switzerland

[9] Ecole Polytech Fed Lausanne, Inst Bioengn, CH-1015 Lausanne, Switzerland

[10] Shahid Beheshti Univ Med Sci, Med Nanotechnol & Tissue Engn Res Ctr, Tehran 1985717444, Iran

[11] Sharif Univ Technol, Dept Mech Engn, Tehran 1136511155, Iran

[12] Stanford Univ, Sch Med, Biomat & Adv Drug Delivery Lab, Palo Alto, CA 94304 USA

来源：

ADVANCED MATERIALS | 2016年 / 28卷 / 21期

关键词：

DRUG-DELIVERY; POLYMERIC NANOPARTICLES; CELLULAR UPTAKE; INTRALUMINAL PH; CHITOSAN; RELEASE;

D O I：

10.1002/adma.201502697

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A microfluidics approach to synthesize core-shell nanocarriers with high pH tunability is described. The sacrificial shell protects the core layer with the drugs and prevents their release in the severe pH conditions of the gastrointestinal tract, while allowing for drug release in the proximity of a tumor. The proposed nanoparticulate drug-delivery system is designed for the oral administration of cancer therapeutics.

引用

页码：4134 / 4141

页数：8

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