Worldwide Burden, Risk Factors, and Temporal Trends of Ovarian Cancer: A Global Study

被引：178

作者：

Huang, Junjie ^{[1
]}

Chan, Wing Chung ^{[1
]}

Ngai, Chun Ho ^{[1
]}

Lok, Veeleah ^{[2
]}

Zhang, Lin ^{[3
,4
]}

Lucero-Prisno, Don Eliseo, III ^{[5
]}

Xu, Wanghong ^{[6
]}

Zheng, Zhi-Jie ^{[7
]}

Elcarte, Edmar ^{[8
]}

Withers, Mellissa ^{[9
]}

Wong, Martin C. S. ^{[1
,4
,7
]}

机构：

[1] Chinese Univ Hong Kong, Fac Med, Jockey Club Sch Publ Hlth & Primary Care, Hong Kong 999077, Peoples R China

[2] Karolinska Univ Hosp, Karolinska Inst, Dept Global Publ Hlth, S-17177 Stockholm, Sweden

[3] Univ Melbourne, Sch Populat & Global Hlth, Melbourne, Vic 3000, Australia

[4] Chinese Acad Med Sci & Peking Union Med Coll, Sch Publ Hlth, Beijing 100005, Peoples R China

[5] London Sch Hyg & Trop Med, Dept Global Hlth & Dev, London WC1E 7HT, England

[6] Fudan Univ, Sch Publ Hlth, Shanghai 200433, Peoples R China

[7] Peking Univ, Sch Publ Hlth, Dept Global Hlth, Beijing 100191, Peoples R China

[8] Univ Philippines, Coll Nursing, Manila 1101, Philippines

[9] Univ Southern Calif, Inst Global Hlth, Dept Prevent Med, Los Angeles, CA 90007 USA

来源：

CANCERS | 2022年 / 14卷 / 09期

关键词：

incidence; mortality; risk factors; temporal trends; ovarian cancer; EPIDEMIOLOGY; CONSUMPTION; COUNTRIES; MORTALITY; WOMEN;

D O I：

10.3390/cancers14092230

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Simple Summary Ovarian cancer was the third most common gynecological cancer globally in 2020. Ovarian carcinoma is the most common type of ovarian cancer, comprising over 90% of all ovarian cancer cases. The risk of ovarian cancer increases in females with age, along with having a family history, having a family cancer syndrome, and breast cancer susceptibility gene (BRCA) mutations. Investigation of the latest disease burden, risk factors, and temporal trends of ovarian cancer is important for the reduction of its associated mortality globally. The global incidence and mortality rates of ovarian cancer for 185 countries in 2020 were retrieved from the Global Cancer Observatory (GLOBOCAN) database established by the International Agency for Research on Cancer (IARC, WHO, Lyon, France). The incidence of ovarian cancer has been increasing substantially among younger females, probably caused by the increasing prevalence of obesity, metabolic syndrome, estrogen exposure and nulliparity. This study aimed to investigate the most updated worldwide incidence and mortality, risk factors, and epidemiologic trend of ovarian cancer in different countries, regions, and age groups. The Global Cancer Observatory database was used for incidence and mortality rates of ovarian cancer in 2020. Data from Cancer Incidence in Five Continents and the WHO mortality database was accessed for trend analysis. Age-standardized rates (ASRs, per 100,000 persons) were calculated for incidence and mortality. The 10-year annual average percent change (AAPC) was estimated by Joinpoint regression analysis. There was an overall decreasing trend of ovarian cancer, yet its burden has been increasing in lower-income countries and among younger females in some countries. Intensive lifestyle modifications are warranted, especially for the populations at high risk for ovarian cancer, including smoking cessation, alcohol use reduction, physical activity, weight control, and treatment of metabolic diseases.

引用

页数：12

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