Structure and function of PH domain.

被引:0
作者
Wang, JC [1 ]
Yao, LB [1 ]
机构
[1] Fourth Mil Med Univ, Dept Biochem & Mol Biol, Xian 710032, Peoples R China
关键词
PH domain; signal transduction; protein kinase C; G protein; phosphatidylinositol derivents;
D O I
暂无
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The PH domain is a protein module of approximately 120 amino acid residues founded in many proteins involved in signal transduction. The PH domains are similar to each other in their three-dimensional structures, and the major structure difference among them lies in the three variable loops in the structures. The PH domain is electrostatically-polarized and the variable loops are on the positively-charged surface, which may serve as a ligand-binding surface. So far, it has been found that PH domains can interact with the beta gamma-subunits of G protein (G beta gamma), protein kinase C (PKC) and phosphatidylinositol-4, 5-bisphosphate ( PIP(2) or inositol-1, 4, 5-trisphosphate (IP(3))). All these implied that PH domain might play an important role in the interaction between the signaling molecules and help to form the signal transduction network.
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收藏
页码:245 / 249
页数:5
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