Anticancer agents targeted against cyclin-dependent kinase 2 (CDK2): Structure-based design of irreversible and reversible inhibitors

被引:0
|
作者
Lebraud, Honorine [1 ]
Golding, Bernard T. [1 ]
Meschini, Elisa [1 ]
Cano, Celine [1 ]
Anscombe, Elizabeth [1 ]
Wang, Lan Z. [1 ]
Endicott, Jane A. [1 ]
Noble, Martin E. M. [1 ]
Newell, David R. [1 ]
Griffin, Roger J. [1 ]
机构
[1] Newcastle Canc Ctr, Dept Med Chem, Northern Inst Canc Res, Newcastle Upon Tyne NE1 7RU, Tyne & Wear, England
来源
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY | 2014年 / 247卷
关键词
D O I
暂无
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
16-MEDI
引用
收藏
页数:1
相关论文
共 50 条
  • [41] Cyclin-dependent kinase 2 (CDK2) opposes T cell anergy and promotes cardiac allograft rejection
    Chunder, Neelanjana
    Wang, Liqing
    Hancock, Wayne
    Wells, Andrew
    JOURNAL OF IMMUNOLOGY, 2010, 184
  • [42] The N-terminal domains of cyclin-dependent kinase inhibitory proteins block the phosphorylation of cdk2/cyclin E by the cdk-activating kinase
    Rank, KB
    Evans, DB
    Sharma, SK
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2000, 271 (02) : 469 - 473
  • [43] Crystallographic approach to identification of cyclin-dependent kinase 4 (CDK4)-specific inhibitors by using CDK4 mimic CDK2 protein
    Ikuta, M
    Kamata, K
    Fukasawa, K
    Honma, T
    Machida, T
    Hirai, H
    Suzuki-Takahashi, I
    Hayama, T
    Nishimura, S
    JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (29) : 27548 - 27554
  • [44] Binding of HTm4 to cyclin-dependent kinase (cdk)-associated phosphatase (KAP)•cdk2•cyclin A complex enhances the phosphatase activity of KAP, dissociates cyclin A, and facilitates KAP dephosphorylation of cdk2
    Chinami, M
    Yano, Y
    Yang, X
    Salahuddin, S
    Moriyama, K
    Shiroishi, M
    Turner, H
    Shirakawa, T
    Adra, CN
    JOURNAL OF BIOLOGICAL CHEMISTRY, 2005, 280 (17) : 17235 - 17242
  • [45] 3D-QSAR CoMFA study on oxindole derivatives as cyclin dependent kinase 1 (CDK1) and cyclin dependent kinase 2 (CDK2) inhibitors
    Singh, Sanjeev Kumar
    Dessalew, Nigus
    Bharatam, Prasad V.
    MEDICINAL CHEMISTRY, 2007, 3 (01) : 75 - 84
  • [46] 3D-QSAR CoMFA study on indenopyrazole derivatives as cyclin dependent kinase 4 (CDK4) and cyclin dependent kinase 2 (CDK2) inhibitors
    Singh, S. K.
    Dessalew, N.
    Bharatam, P. V.
    EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2006, 41 (11) : 1310 - 1319
  • [47] Design, synthesis and biological evaluation of novel histone deacetylase1/2 (HDAC1/2) and cyclin-dependent Kinase2 (CDK2) dual inhibitors against malignant cancer
    Yun, Fan
    Cheng, Chunhui
    Ullah, Sadeeq
    Yuan, Qipeng
    EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2020, 198
  • [48] Understanding and modulating cyclin-dependent kinase inhibitor specificity: molecular modeling and biochemical evaluation of pyrazolopyrimidinones as CDK2/cyclin A and CDK4/cyclin D1 inhibitors
    Rossi, KA
    Markwalder, JA
    Seitz, SP
    Chang, CH
    Cox, S
    Boisclair, MD
    Brizuela, L
    Brenner, SL
    Stouten, PFW
    JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN, 2005, 19 (02) : 111 - 122
  • [49] Understanding and modulating cyclin-dependent kinase inhibitor specificity: molecular modeling and biochemical evaluation of pyrazolopyrimidinones as CDK2/cyclin A and CDK4/cyclin D1 inhibitors
    Karen A. Rossi
    Jay A. Markwalder
    Steven P. Seitz
    Chong-Hwan Chang
    Sarah Cox
    Michael D. Boisclair
    Leonardo Brizuela
    Stephen L. Brenner
    Pieter F. W. Stouten
    Journal of Computer-Aided Molecular Design, 2005, 19 : 111 - 122
  • [50] Dephosphorylation of Cdk2 Thr160 by the cyclin-dependent kinase-interacting phosphatase KAP in the absence of cyclin
    1600, American Assoc for the Advancement of Science, Washington, DC, USA (270):