Anticancer agents targeted against cyclin-dependent kinase 2 (CDK2): Structure-based design of irreversible and reversible inhibitors

被引:0
|
作者
Lebraud, Honorine [1 ]
Golding, Bernard T. [1 ]
Meschini, Elisa [1 ]
Cano, Celine [1 ]
Anscombe, Elizabeth [1 ]
Wang, Lan Z. [1 ]
Endicott, Jane A. [1 ]
Noble, Martin E. M. [1 ]
Newell, David R. [1 ]
Griffin, Roger J. [1 ]
机构
[1] Newcastle Canc Ctr, Dept Med Chem, Northern Inst Canc Res, Newcastle Upon Tyne NE1 7RU, Tyne & Wear, England
来源
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY | 2014年 / 247卷
关键词
D O I
暂无
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
16-MEDI
引用
收藏
页数:1
相关论文
共 50 条
  • [1] Structure-based design of cyclin-dependent kinase inhibitors
    Davies, TG
    Pratt, DJ
    Endicott, JA
    Johnson, LN
    Noble, MEM
    PHARMACOLOGY & THERAPEUTICS, 2002, 93 (2-3) : 125 - 133
  • [2] Cyclin-dependent kinase inhibitors as potential targeted anticancer agents
    Diaz-Padilla, Ivan
    Siu, Lillian L.
    Duran, Ignacio
    INVESTIGATIONAL NEW DRUGS, 2009, 27 (06) : 586 - 594
  • [3] Cyclin-dependent kinase inhibitors as potential targeted anticancer agents
    Ivan Diaz-Padilla
    Lillian L. Siu
    Ignacio Duran
    Investigational New Drugs, 2009, 27 : 586 - 594
  • [4] Discovery of Selective Tertiary Amide Inhibitors of Cyclin-Dependent Kinase 2 (CDK2)
    Zeng, Mingshuo
    Grandner, Jessica M.
    Bryan, Marian C.
    Verma, Vishal
    Larouche-Gauthier, Robin
    Leclerc, Jean-Philippe
    Zhao, Liang
    Haghshenas, Pouyan
    Aubert-Nicol, Samuel
    Yadav, Arun
    Ashley, Melissa
    Chen, Jacob Z.
    Durk, Matthew
    Samy, Karen E.
    Nespi, Marika
    Levy, Elizabeth
    Merrick, Karl
    Moffat, John G.
    Murray, Jeremy
    Oh, Angela
    Orr, Christine
    Segal, Ehud
    Sims, Jessica
    Sneeringer, Christopher
    Prangley, Madeleine
    Vartanian, Steffan
    Magnuson, Steven
    Parr, Brendan T.
    ACS MEDICINAL CHEMISTRY LETTERS, 2023, 14 (09): : 1179 - 1187
  • [5] Design, Synthesis, Anticancer Activity and Docking Studies of Thiazole Linked Phenylsulfone Moiety as Cyclin-Dependent Kinase 2 (CDK2) Inhibitors
    Farghaly, Thoraya A.
    Al-Hasani, Wedian A.
    Ibrahim, Mona H.
    Abdellattif, Magda H.
    Abdallah, Zeinab A.
    POLYCYCLIC AROMATIC COMPOUNDS, 2023, 43 (06) : 5001 - 5020
  • [6] Transforming growth factor β targeted inactivation of cyclin E:cyclin-dependent kinase 2 (Cdk2) complexes by inhibition of Cdk2 activating kinase activity
    Nagahara, H
    Ezhevsky, SA
    Vocero-Akbani, AM
    Kaldis, P
    Solomon, MJ
    Dowdy, SF
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (26) : 14961 - 14966
  • [7] The cyclin-dependent kinase Cdk2 regulates thymocyte apoptosis
    Hakem, A
    Sasaki, T
    Kozieradzki, I
    Penninger, JM
    JOURNAL OF EXPERIMENTAL MEDICINE, 1999, 189 (06): : 957 - 967
  • [8] Structure-based discovery of the first allosteric inhibitors of cyclin-dependent kinase 2
    Rastelli, Giulio
    Anighoro, Andrew
    Chripkova, Martina
    Carrassa, Laura
    Broggini, Massimo
    CELL CYCLE, 2014, 13 (14) : 2296 - 2305
  • [9] Cyclin-dependent kinase inhibitors: novel anticancer agents
    Mani, S
    Wang, CG
    Wu, KM
    Francis, R
    Pestell, R
    EXPERT OPINION ON INVESTIGATIONAL DRUGS, 2000, 9 (08) : 1849 - 1870
  • [10] A comprehensive bioinformatic analysis of cyclin-dependent kinase 2 (CDK2) in glioma
    Liu, Hengrui
    Weng, Jieling
    GENE, 2022, 822