Resveratrol loaded oxidized mesoporous carbon nanoparticles: A promising tool to treat triple negative breast cancer

被引：25

作者：

Fan, Conghui ^{[1
]}

Kong, Fanhui ^{[1
]}

Shetti, Dattatrya ^{[1
]}

Zhang, Bao ^{[1
]}

Yang, Yeguo ^{[1
]}

Wei, Kun ^{[1
]}

机构：

[1] South China Univ Technol, Sch Biol & Biol Engn, Guangzhou 510006, Peoples R China

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2019年 / 519卷 / 02期

关键词：

Triple negative breast cancer; Resveratrol; Mesoporous carbon nanoparticles; Solubility; Cytotoxicity; Apoptosis; ORAL BIOAVAILABILITY; DELIVERY; DRUGS; SIZE;

D O I：

10.1016/j.bbrc.2019.09.016

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Currently, breast cancer has become the most commonly diagnosed malignancy among females and triple negative breast cancer (TNBC) is a highly aggressive and metastatic subtype. The natural polyphenolic compound, resveratrol (3, 4', 5-trihydroxy-trans-stilbene, RES), has drawn great attention for its potential against TNBC. However, due to the poor aqueous solubility, the bioactivity of RES against TNBC is extremely hampered. In this study, oxidized mesoporous carbon nanoparticles (oMCNs) with size below 200 nm and excellent water dispersibility were synthesized using mild oxidation method and RES was successfully encapsulated into the pores of oMCNs with high drug loading efficiency (24.8% w/w). oMCNs exhibited good biocompatibility and excellent cellular uptake efficiency. Compared to pure RES, oMCNs-RES greatly improved the saturated solubility and in vitro release property. In vitro cytoxicity assay and apoptosis analysis showed that oMCNs-RES induced enhanced cytotoxic effect and proapoptosis effect mediated via the PARR and Caspase-3 protein cleavage in TNBC cell line, respectively. These results demonstrate oMCNs have the potential to deliver hydrophobic drugs and oMCNs-RES are promising in treating TNBC. (C) 2019 Elsevier Inc. All rights reserved.

引用

页码：378 / 384

页数：7

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