Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes Insights Into Molecular, Cellular, and Functional Phenotypes

被引：348

作者：

Karakikes, Ioannis ^{[1
,2
]}

Ameen, Mohamed ^{[1
]}

Termglinchan, Vittavat ^{[1
,2
]}

Wu, Joseph C. ^{[1
,2
,3
]}

机构：

[1] Stanford Univ, Sch Med, Stanford Cardiovasc Inst, Stanford, CA 94305 USA

[2] Stanford Univ, Sch Med, Dept Med, Div Cardiovasc Med, Stanford, CA 94305 USA

[3] Stanford Univ, Sch Med, Inst Stem Cell Biol & Regenerat Med, Stanford, CA 94305 USA

来源：

CIRCULATION RESEARCH | 2015年 / 117卷 / 01期

基金：

美国国家卫生研究院;

关键词：

cardiovascular diseases; cardiovascular disease modeling; induced pluripotent stem cells; myocytes; cardiac; precision medicine; CARDIAC DIFFERENTIATION; HEART-FAILURE; ANIMAL-MODELS; MATURATION; DISEASE; CARDIOMYOPATHY; PURIFICATION; CULTURE; TISSUE; MOUSE;

D O I：

10.1161/CIRCRESAHA.117.305365

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Disease models are essential for understanding cardiovascular disease pathogenesis and developing new therapeutics. The human induced pluripotent stem cell (iPSC) technology has generated significant enthusiasm for its potential application in basic and translational cardiac research. Patient-specific iPSC-derived cardiomyocytes offer an attractive experimental platform to model cardiovascular diseases, study the earliest stages of human development, accelerate predictive drug toxicology tests, and advance potential regenerative therapies. Harnessing the power of iPSC-derived cardiomyocytes could eliminate confounding species-specific and interpersonal variations and ultimately pave the way for the development of personalized medicine for cardiovascular diseases. However, the predictive power of iPSC-derived cardiomyocytes as a valuable model is contingent on comprehensive and rigorous molecular and functional characterization.

引用

页码：80 / 88

页数：9

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