Association analysis of serotonin 2A receptor gene T102c polymorphism and schizophrenia

被引：12

作者：

Czerski, PM ^{[1
]}

Leszczynska-Rodziewicz, A ^{[1
]}

Dmitrzak-Weglarz, M ^{[1
]}

Kapelski, P ^{[1
]}

Godlewski, S ^{[1
]}

Rybakowski, J ^{[1
]}

Hauser, J ^{[1
]}

机构：

[1] Univ Med Sci, Dept Adult Psychiat, Lab Psychiat Genet, PL-60587 Poznan, Poland

来源：

WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY | 2003年 / 4卷 / 02期

关键词：

serotonin receptor; genetics; polymorphism; schizophrenia;

D O I：

10.3109/15622970309167954

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

The serotonin neurotransmitter has been associated with the pathogenesis of mood disorders and schizophrenia. Serotonin receptors genes may therefore be candidate genes for the study of the genetics of these disorders. In this study, patients with schizophrenia (n=235) and controls (n=344) were analysed to determine the correlation between the 5HT(2A) receptor gene T102C polymorphism and schizophrenia. No association was found between the studied polymorphism and schizophrenia (p=0.854 for alleles and p=0.945 for genotypes). Results were also not significant when analysed by gender (for male p=0.861-allele frequency and p=0.467-genotype frequency, for female p=0.857-allele frequency and p=0.833-genotype frequency). Subgroups with regard to schizophrenia subtypes, age or onset and clinical course of schizophrenia were analysed with negative results.

引用

页码：69 / 73

页数：5

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