The Role of Pentraxin 3 in Aspergillosis: Reality and Prospects

被引：20
作者：
Kang, Yuening [1 ]
Yu, Yuetian [2 ]
Lu, Liangjing [1 ]
机构：
[1] Shanghai Jiao Tong Univ, Sch Med, Renji Hosp, Dept Rheumatol, Shanghai, Peoples R China
[2] Shanghai Jiao Tong Univ, Sch Med, Ren Ji Hosp, Dept Crit Care Med, Shanghai, Peoples R China
来源：
MYCOBIOLOGY | 2020年 / 48卷 / 01期
基金：
中国国家自然科学基金;
关键词：
Pentraxin; 3; Aspergillus; invasive aspergillosis; PATTERN-RECOGNITION MOLECULE; INVASIVE ASPERGILLOSIS; INNATE IMMUNITY; FACTOR-H; PULMONARY ASPERGILLOSIS; PROTECTIVE ACTIVITY; REACTIVE PROTEIN; PTX3; DEFICIENCY; TISSUE-REPAIR; COMPLEMENT;
D O I：
10.1080/12298093.2020.1722576
中图分类号：
S3 [农学（农艺学）];
学科分类号：
0901 ;
摘要：
Pentraxin 3 (PTX3) is a soluble pattern recognition receptor (PRR), which is produced by several kinds of cells, such as neutrophils, dendritic cells, macrophages, and epithelial cells. PTX3 is known to play an important protective effect against Aspergillus. Genetic linkage in gene-targeted mice and human PTX3 plays a non-redundant role in the immune protection against specific pathogens, especially Aspergillus. Recent studies have shown that the polymorphism of PTX3 is associated with increased susceptibility to invasive aspergillosis (IA). In this review, we provide an overview of these studies that underline the potential of PTX3 in diagnosis and therapy of IA.
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页码：1 / 8
页数：8
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