Metastatic pancreatic cancer response to treatment with cetuximab and gemcitabine plus capecitabine: a case report and review of the literature

被引:1
作者
Li, Mei [1 ]
Jiang, Ming [1 ]
Yan, Xi [1 ]
Wang, Feng [1 ]
Luo, Feng [1 ]
机构
[1] Sichuan Univ, Ctr Canc, State Key Lab Biotherapy, W China Hosp, Chengdu 610064, Sichuan Prov, Peoples R China
来源
TUMORI JOURNAL | 2010年 / 96卷 / 05期
关键词
cetuximab; gemcitabine; capecitabine; pancreatic cancer; MULTICENTER; SURVIVAL;
D O I
10.1177/030089161009600520
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
The treatment of pancreatic cancer remains a formidable challenge to clinicians. Here we describe the case of a 57-year-old man with metastatic pancreatic cancer who received combination treatment with cetuximab and capecitabine plus gemcitabine for four cycles. Repeat CT scan showed that the size of both the primary tumor in the pancreas and the metastatic lesions in the liver had shrunk significantly. Rapid reduction of the serum CA19-9 level was observed, and no serious toxic events occurred. The patient had a progression-free survival of eight months at the time we wrote this paper. The combination of cetuximab and capecitabine plus gemcitabine may be a useful therapy in metastatic pancreatic cancer. Free full text available at www.tumorionline.it
引用
收藏
页码:764 / 767
页数:4
相关论文
共 10 条
[1]   Cetuximab plus gemcitabine and cisplatin compared with gemcitabine and cisplatin alone in patients with advanced pancreatic cancer: a randomised, multicentre, phase II trial [J].
不详 .
LANCET ONCOLOGY, 2008, 9 (01) :39-44
[2]   Improvements in survival and clinical benefit with gemcitabine as first-line therapy for patients with advanced pancreas cancer: A randomized trial [J].
Burris, HA ;
Moore, MJ ;
Andersen, J ;
Green, MR ;
Rothenberg, ML ;
Madiano, MR ;
Cripps, MC ;
Portenoy, RK ;
Storniolo, AM ;
Tarassoff, P ;
Nelson, R ;
Dorr, FA ;
Stephens, CD ;
VanHoff, DD .
JOURNAL OF CLINICAL ONCOLOGY, 1997, 15 (06) :2403-2413
[3]   New therapeutic directions for advanced pancreatic cancer: Targeting the epidermal growth factor and vascular endothelial growth factor pathways [J].
Burris, Howard, III ;
Rocha-Lima, Caio .
ONCOLOGIST, 2008, 13 (03) :289-298
[4]   Gemcitabine plus capecitabine compared with gemcitabine alone in advanced pancreatic cancer:: A randomized, multicenter, phase III trial of the Swiss Group for Clinical Cancer Research and the Central European Cooperative Oncology Group [J].
Herrmann, Richard ;
Bodoky, Gyoergy ;
Ruhstaller, Thomas ;
Glimelius, Bengt ;
Bajetta, Emilio ;
Schueller, Johannes ;
Saletti, Piercarlo ;
Bauer, Jean ;
Figer, Arie ;
Pestalozzi, Bernhard ;
Koehne, Claus-Henning ;
Mingrone, Walter ;
Stemmer, Salomon M. ;
Tamas, Karin ;
Kornek, Gabriela V. ;
Koeberle, Dieter ;
Cina, Susanne ;
Bernhard, Juerg ;
Dietrich, Daniel ;
Scheithauer, Werner .
JOURNAL OF CLINICAL ONCOLOGY, 2007, 25 (16) :2212-2217
[5]   Cetuximab plus gemcitabine/oxaliplatin (GEMOXCET) in first-line metastatic pancreatic cancer: a multicentre phase II study [J].
Kullmann, F. ;
Hollerbach, S. ;
Dollinger, M. M. ;
Harder, J. ;
Fuchs, M. ;
Messmann, H. ;
Trojan, J. ;
Gaebele, E. ;
Hinke, A. ;
Hollerbach, C. ;
Endlicher, E. .
BRITISH JOURNAL OF CANCER, 2009, 100 (07) :1032-1036
[6]   Mutational analyses of multiple oncogenic pathways in intraductal papillary mucinous neoplasms of the pancreas [J].
Nleben, Frank Scho ;
Allendorf, John D. ;
Qiu, Wanglong ;
Li, Xiaojun ;
Ho, Daniel J. ;
Ciau, Nancy T. ;
Fine, Robert L. ;
Chabot, John A. ;
Remotti, Helen E. ;
Su, Gloria H. .
PANCREAS, 2008, 36 (02) :168-172
[7]   Global cancer statistics, 2002 [J].
Parkin, DM ;
Bray, F ;
Ferlay, J ;
Pisani, P .
CA-A CANCER JOURNAL FOR CLINICIANS, 2005, 55 (02) :74-108
[8]  
Philip PA, 2007, J CLIN ONCOL, V25, DOI 10.1200/JCO.2006.09.6040
[9]   Pancreatic cancer: A report of treatment and survival trends for 100,313 patients diagnosed from 1985-1995, using the National Cancer Database [J].
Sener, SF ;
Fremgen, A ;
Menck, HR ;
Winchester, DP .
JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS, 1999, 189 (01) :1-7
[10]   Meta-analyses of chemotherapy for locally advanced and metastatic pancreatic cancer [J].
Sultana, Asma ;
Smith, Catrin Tudur ;
Cunningham, David ;
Starling, Naureen ;
Neoptolemos, John P. ;
Ghaneh, Paula .
JOURNAL OF CLINICAL ONCOLOGY, 2007, 25 (18) :2607-2615