The core of hepatitis C virus pathogenesis

被引：21
作者：
Kao, C. Cheng [1 ]
Yi, Guanghui [1 ]
Huang, Hsuan-Cheng [2 ]
机构：
[1] Indiana Univ, Dept Mol & Cellular Biochem, Bloomington, IN 47405 USA
[2] Natl Yang Ming Univ, Inst Biomed Informat, Taipei 11221, Taiwan
来源：
CURRENT OPINION IN VIROLOGY | 2016年 / 17卷
关键词：
INTERFERON-STIMULATED GENES; ACTING RNA ELEMENTS; HEPATOCELLULAR-CARCINOMA; T-CELLS; PROTEIN-INTERACTION; MEDIATED APOPTOSIS; NATURAL-HISTORY; UP-REGULATION; HCV; EXPRESSION;
D O I：
10.1016/j.coviro.2016.01.009
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Capsid proteins form protective shells around viral genomes and mediate viral entry. However, many capsid proteins have additional and important roles for virus infection and in modulating cellular response to infection, with important consequences on pathogenesis. Infection by the Hepatitis C virus (HCV) can lead to liver steatosis, cirrhosis, and hepatocellular carcinoma. Herein, we focus on the role in pathogenesis of Core, the capsid protein of the HCV.
引用
收藏
页码：66 / 73
页数：8
相关论文
共 114 条
  • [1] Regulation of core expression during the hepatitis C virus life cycle
    Afzal, Muhammad Sohail
    Alsaleh, Khaled
    Farhat, Rayan
    Belouzard, Sandrine
    Danneels, Adeline
    Descamps, Veronique
    Duverlie, Gilles
    Wychowski, Czeslaw
    Zaidi, Najam Us Sahar Sadaf
    Dubuisson, Jean
    Rouille, Yves
    [J]. JOURNAL OF GENERAL VIROLOGY, 2015, 96 : 311 - 321
  • [2] Amino acid substitutions in the hepatitis c virus core region are the important predictor of hepatocarcinogenesis
    Akuta, Norio
    Suzuki, Fumitaka
    Kawamura, Yusuke
    Yatsuji, Hiromi
    Sezaki, Hitomi
    Suzuki, Yoshiyuki
    Hosaka, Tetsuya
    Kobayashi, Masahiro
    Kobayashi, Mariko
    Arase, Yasuji
    Ikeda, Kenji
    Kumadal, Hiromitsu
    [J]. HEPATOLOGY, 2007, 46 (05) : 1357 - 1364
  • [3] Hepatitis C virus infection and type 1 and type 2 diabetes mellitus
    Antonelli, Alessandro
    Ferrari, Silvia Martina
    Giuggioli, Dilia
    Di Domenicantonio, Andrea
    Ruffilli, Ilaria
    Corrado, Alda
    Fabiani, Silvia
    Marchi, Santino
    Ferri, Clodoveo
    Ferrannini, Ele
    Fallahi, Poupak
    [J]. WORLD JOURNAL OF DIABETES, 2014, 5 (05) : 586 - 600
  • [4] Memory CD8+ T cells vary in differentiation phenotype in different persistent virus infections
    Appay, V
    Dunbar, PR
    Callan, M
    Klenerman, P
    Gillespie, GMA
    Papagno, L
    Ogg, GS
    King, A
    Lechner, F
    Spina, CA
    Little, S
    Havlir, DV
    Richman, DD
    Gruener, N
    Pape, G
    Waters, A
    Easterbrook, P
    Salio, M
    Cerundolo, V
    McMichael, AJ
    Rowland-Jones, SL
    [J]. NATURE MEDICINE, 2002, 8 (04) : 379 - 385
  • [5] Hepatitis C Virus Controls Interferon Production through PKR Activation
    Arnaud, Noella
    Dabo, Stephanie
    Maillard, Patrick
    Budkowska, Agata
    Kalliampakou, Katerina I.
    Mavromara, Penelope
    Garcin, Dominique
    Hugon, Jacques
    Gatignol, Anne
    Akazawa, Daisuke
    Wakita, Takaji
    Meurs, Eliane F.
    [J]. PLOS ONE, 2010, 5 (05):
  • [6] Oncogenic Potential of Hepatitis C Virus Proteins
    Banerjee, Arup
    Ray, Ratna B.
    Ray, Ranjit
    [J]. VIRUSES-BASEL, 2010, 2 (09): : 2108 - 2133
  • [7] Hepatitis C virus core protein shows a cytoplasmic localization and associates to cellular lipid storage droplets
    Barba, G
    Harper, F
    Harada, T
    Kohara, M
    Goulinet, S
    Matsuura, Y
    Eder, G
    Schaff, Z
    Chapman, MJ
    Miyamura, T
    Brechot, C
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1997, 94 (04) : 1200 - 1205
  • [8] Microarray analyses and molecular profiling of Stat3 signaling pathway induced by hepatitis C virus core protein in human hepatocytes
    Basu, Arnab
    Meyer, Keith
    Lai, Keith K.
    Saito, Kousuke
    Di Bisceglie, Adrian M.
    Grosso, Leonard E.
    Ray, Ratna B.
    Ray, Ranjit
    [J]. VIROLOGY, 2006, 349 (02) : 347 - 358
  • [9] To kill or be killed: viral evasion of apoptosis
    Benedict, CA
    Norris, PS
    Ware, CF
    [J]. NATURE IMMUNOLOGY, 2002, 3 (11) : 1013 - 1018
  • [10] HCV core-mediated activation of latent TGF-β via thrombospondin drives the crosstalk between hepatocytes and stromal environment
    Benzoubir, Nassima
    Lejamtel, Charlene
    Battaglia, Serena
    Testoni, Barbara
    Benassi, Barbara
    Gondeau, Claire
    Perrin-Cocon, Laure
    Desterke, Christophe
    Thiers, Valerie
    Samuel, Didier
    Levrero, Massimo
    Brechot, Christian
    Bourgeade, Marie-Francoise
    [J]. JOURNAL OF HEPATOLOGY, 2013, 59 (06) : 1160 - 1168
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