Genetic Risk Models in Age-Related Macular Degeneration

被引：8

作者：

Grassmann, Felix ^{[1
]}

Heid, Iris M. ^{[2
,3
]}

Weber, Bernhard H. F. ^{[1
]}

机构：

[1] Univ Regensburg, Inst Human Genet, D-93053 Regensburg, Germany

[2] Univ Regensburg, Dept Genet Epidemiol, D-93053 Regensburg, Germany

[3] Helmholtz Zentrum Munchen, Inst Genet Epidemiol, German Res Ctr Environm Hlth, D-85764 Neuherberg, Germany

来源：

RETINAL DEGENERATIVE DISEASES: MECHANISMS AND EXPERIMENTAL THERAPY | 2014年 / 801卷

关键词：

Age-related macular degeneration; Susceptibility; Logistic regression; Cox regression; Genetic risk score; CLINICAL-TRIAL; UNITED-STATES; PREVALENCE; CFH; PROGRESSION; SEVERITY; C2;

D O I：

10.1007/978-1-4614-3209-8_37

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Late-stage age-related macular degeneration (AMD) is a common sight-threatening disease of the central retina affecting approximately 1 in 30 Caucasians. Besides age and smoking, common genetic variants from at least 19 gene loci have reproducibly been associated with AMD likely explaining a large proportion of disease. Based on the current knowledge, several models were calculated to predict disease risk each with its own strength and weakness. Here, we review and compare published genetic risk models for AMD with or without additionally accounting for non-genetic factors.

引用

页码：291 / 300

页数：10

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