Solid-Liquid Equilibrium of Lamotrigine in 12 Pure Solvents from T=283.15 to 323.15 K: Experimental Determination and Thermodynamic Modeling

被引：10

作者：

Kuang, Wenjie ^{[1
]}

Ji, Shaochang ^{[2
]}

Wang, Xiaofang ^{[3
]}

Liao, Anping ^{[1
]}

Lan, Ping ^{[1
]}

Zhang, Jinyan ^{[1
]}

机构：

[1] Guangxi Univ Nationalities, Guangxi Key Lab Polysaccharide Mat & Their Modifi, Key Lab Chem & Biol Transformat Proc Guangxi High, Coll Chem & Chem Engn, Nanning 530006, Guangxi, Peoples R China

[2] Guangxi Tobacco Monopoly Bur, Nanning 530006, Guangxi, Peoples R China

[3] Petr Engn Res Inst Petrochina Dagang Oilfield, Tianjin 300000, Peoples R China

来源：

JOURNAL OF CHEMICAL AND ENGINEERING DATA | 2020年 / 65卷 / 01期

基金：

中国国家自然科学基金;

关键词：

MAGNESIUM-DL-ASPARTATE; P-TOLUIC ACID; SOLUBILITY; PROPANOL; METHANOL; BROMIDE; ETHANOL; DRUG;

D O I：

10.1021/acs.jced.9b00856

中图分类号：

O414.1 [热力学];

学科分类号：

摘要：

The solubility of lamotrigine in 12 pure solvents, including 1-propanol, isopropanol, 1-butanol, isobutanol, acetone, ethyl propionate, methyl acetate, ethanol, methyl isobutyl ketone, n-pentanol, water, and 2-butanol, was measured by using the static method in a temperature range from 283.15 to 323.15 K under atmospheric pressure (101.1 kPa). The experimental solubility data were correlated by the modified Apelblat equation, lambda h equation, nonrandom two-liquid (NRTL) models, and Wilson models. The model parameters and data error were calculated. The maximum values of root-mean-square deviation were 4.299 x 10(-4). As a result, the Apelblat model provided the best fitting. The solubility data provide the basic data for the design and optimization of lamotrigine crystallization.

引用

页码：169 / 176

页数：8

共 31 条

[1] Solubilities of o-acetylsalicylic, 4-aminosalicylic, 3,5-dinitrosalicylic, and p-toluic acid, and magnesium-DL-aspartate in water from T = (278 to 348) K [J].

Apelblat, A ;

Manzurola, E .

JOURNAL OF CHEMICAL THERMODYNAMICS, 1999, 31 (01) :85-91

[2] The effect of 1-hexyl-3-methylimidazolium bromide ionic liquid as a co-solvent on the aqueous solubility of lamotrigine at T = (293.2-313.2) K [J].

Barzegar-Jalali, Mohammad ;

Jouyban, Abolghasem ;

Shekaari, Hemayat ;

Martinez, Fleming ;

Mirheydari, Seyyedeh Narjes .

JOURNAL OF CHEMICAL THERMODYNAMICS, 2019, 133 :261-271

[3] SOLVENT ACTIVITY ALONG A SATURATION LINE AND SOLUBILITY OF HYDROGEN-BONDING SOLIDS [J].

BUCHOWSKI, H ;

KSIAZCZAK, A ;

PIETRZYK, S .

JOURNAL OF PHYSICAL CHEMISTRY, 1980, 84 (09) :975-979

[4] Low solubility in drug development: de-convoluting the relative importance of solvation and crystal packing [J].

Docherty, Robert ;

Pencheva, Klimentina ;

Abramov, Yuriy A. .

JOURNAL OF PHARMACY AND PHARMACOLOGY, 2015, 67 (06) :847-856

[5]

Dubovsky SL, 1997, J CLIN PSYCHIAT, V58, P224

[6] Lamotrigine Solubility in Some Nonaqueous Solvent Mixtures at 298.2 K [J].

Farjami, Afsaneh ;

Jouyban, Abolghasem .

JOURNAL OF CHEMICAL AND ENGINEERING DATA, 2015, 60 (08) :2490-2494

[7] Measurement and prediction of solubilities of active pharmaceutical ingredients [J].

Hahnenkamp, Inga ;

Graubner, Gitte ;

Gmehling, Juergen .

INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2010, 388 (1-2) :73-81

[8]

Hanna M., 2011, WO Patent, Patent No. [2,011,097,269, 2011097269]

[9]

Jones A.G., 2002, Crystallization process systems

[10]

Jouyban A, 2010, HDB SOLUBILITY DATA, V3, P198

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