Emerging role of mitophagy in human diseases and physiology

被引：152
作者：
Um, Jee-Hyun [1 ,2 ]
Yun, Jeanho [1 ,2 ]
机构：
[1] Dong A Univ, Coll Med, Dept Biochem, Busan 49201, South Korea
[2] Dong A Univ, Coll Med, Peripheral Neuropathy Res Ctr, Busan 49201, South Korea
来源：
BMB REPORTS | 2017年 / 50卷 / 06期
基金：
新加坡国家研究基金会;
关键词：
Mitophagy; human diseases; human physiology; Mitochondria dysfunctions; mitophagy activity; TUMOR-SUPPRESSOR GENE; MITOCHONDRIAL-DNA; ADRENOCORTICAL TUMORS; PERIPHERAL NEUROPATHY; PARKIN; AUTOPHAGY; DEGRADATION; PROTEIN; PINK1; BNIP3;
D O I：
10.5483/BMBRep.2017.50.6.056
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Mitophagy is a process of selective removal of damaged or unnecessary mitochondria using autophagic machinery. Mitophagy plays an essential role in maintaining mitochondrial quality control and homeostasis. Mitochondrial dysfunctions and defective mitophagy in neurodegenerative diseases, cancer, and metabolic diseases indicate a close link between human disease and mitophagy. Furthermore, recent studies showing the involvement of mitophagy in differentiation and development, suggest that mitophagy may play a more active role in controlling cellular functions. A better understanding of mitophagy will provide insights about human disease and offer novel chance for treatment. This review mainly focuses on the recent implications for mitophagy in human diseases and normal physiology.
引用
收藏
页码：299 / 307
页数：9
相关论文
共 80 条
[1]   Postfertilization Autophagy of Sperm Organelles Prevents Paternal Mitochondrial DNA Transmission [J].
Al Rawi, Sara ;
Louvet-Vallee, Sophie ;
Djeddi, Abderazak ;
Sachse, Martin ;
Culetto, Emmanuel ;
Hajjar, Connie ;
Boyd, Lynn ;
Legouis, Renaud ;
Galy, Vincent .
SCIENCE, 2011, 334 (6059) :1144-1147
[2]   Loss of iron triggers PINK1/Parkin-independent mitophagy [J].
Allen, George F. G. ;
Toth, Rachel ;
James, John ;
Ganley, Ian G. .
EMBO REPORTS, 2013, 14 (12) :1127-1135
[3]   The pathways of mitophagy for quality control and clearance of mitochondria [J].
Ashrafi, G. ;
Schwarz, T. L. .
CELL DEATH AND DIFFERENTIATION, 2013, 20 (01) :31-42
[4]   Mitophagy of damaged mitochondria occurs locally in distal neuronal axons and requires PINK1 and Parkin [J].
Ashrafi, Ghazaleh ;
Schlehe, Julia S. ;
LaVoie, Matthew J. ;
Schwarz, Thomas L. .
JOURNAL OF CELL BIOLOGY, 2014, 206 (05) :655-670
[5]   Mitochondrial protein quality control in health and disease [J].
Baker, Michael J. ;
Palmer, Catherine S. ;
Stojanovski, Diana .
BRITISH JOURNAL OF PHARMACOLOGY, 2014, 171 (08) :1870-1889
[6]   PTEN-inducible kinase 1 (PINK1)/Park6 is indispensable for normal heart function [J].
Billia, Filio ;
Hauck, Ludger ;
Konecny, Filip ;
Rao, Vivek ;
Shen, Jie ;
Mak, Tak Wah .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2011, 108 (23) :9572-9577
[7]   Disturbed mitochondrial dynamics and neurodegenerative disorders [J].
Burte, Florence ;
Carelli, Valerio ;
Chinnery, Patrick F. ;
Yu-Wai-Man, Patrick .
NATURE REVIEWS NEUROLOGY, 2015, 11 (01) :11-24
[8]   Mechanistic and prognostic significance of aberrant methylation in the molecular pathogenesis of human hepatocellular carcinoma [J].
Calvisi, Diego F. ;
Ladu, Sara ;
Gorden, Alexis ;
Farina, Miriam ;
Lee, Ju-Seog ;
Conner, Elizabeth A. ;
Schroeder, Insa ;
Factor, Valentina M. ;
Thorgeirsson, Snorri S. .
JOURNAL OF CLINICAL INVESTIGATION, 2007, 117 (09) :2713-2722
[9]   Parkin, a gene implicated in autosomal recessive juvenile parkinsonism, is a candidate tumor suppressor gene on chromosome 6q25-q27 (Publication with Expression of Concern. See vol. 114, 2017) [J].
Cesari, R ;
Martin, ES ;
Calin, GA ;
Pentimalli, F ;
Bichi, R ;
McAdams, H ;
Trapasso, F ;
Drusco, A ;
Shimizu, M ;
Mascillo, V ;
d'Andrilli, G ;
Scambia, G ;
Picchio, MC ;
Alder, H ;
Godwin, AK ;
Croce, CM .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (10) :5956-5961
[10]   The role of mitochondrial DNA mutation on neurodegenerative diseases [J].
Cha, Moon-Yong ;
Kim, Dong Kyu ;
Mook-Jung, Inhee .
EXPERIMENTAL AND MOLECULAR MEDICINE, 2015, 47 :e150-e150
12345678