Pancreatic cancer from bench to bedside: molecular pathways and treatment options

被引：17

作者：

Kosmidis, Christoforos ^{[1
]}

Sapalidis, Konstantinos ^{[1
]}

Kotidis, Efstathios ^{[1
]}

Mixalopoulos, Nikolaos ^{[1
]}

Zarogoulidis, Paul ^{[2
]}

Tsavlis, Drosos ^{[2
]}

Baka, Sofia ^{[3
]}

Man, Yan-Gao ^{[4
,5
]}

Kanellos, John ^{[1
]}

机构：

[1] Univ Gen Hosp Thessaloniki AHEPA, AUTH, Dept Surg 3, Thessaloniki, Greece

[2] Aristotle Univ Thessaloniki, G Papanikolaou Gen Hosp, Oncol Unit, Dept Pulm, Thessaloniki, Greece

[3] Interbalkan Med Ctr Thessaloniki, Dept Oncol, Thessaloniki, Greece

[4] Bon Secours Canc Inst, Res Lab, Richmond, VA USA

[5] Bon Secours Canc Inst, Int Collaborat, Richmond, VA USA

来源：

ANNALS OF TRANSLATIONAL MEDICINE | 2016年 / 4卷 / 09期

关键词：

Pancreatic cancer (PC); molecular pathways; targeted treatment; PHASE-III TRIAL; PAPILLARY MUCINOUS NEOPLASM; GROWTH-FACTOR RECEPTOR; MTOR INHIBITOR EVEROLIMUS; GEMCITABINE PLUS PLACEBO; ONCOLYTIC VIRUSES; DOUBLE-BLIND; TARGETED THERAPIES; METASTATIC ADENOCARCINOMA; CHEMORADIATION THERAPY;

D O I：

10.21037/atm.2016.05.11

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

In the last forty years the pancreatic cancer treatment has made advances, however; still novel drugs are needed. It is known that the five year survival rate remains around 5%. The best treatment option still remains surgery, if patients are diagnosed early. In the last decade the biology of pancreatic cancer has been vastly explored and novel agents such as; tyrosine kinase agents, or vaccines have been added as a treatment perspective. The big challenge is now to translate this knowledge in better outcomes for patients. In this current review we will present information from pancreatic cancer diagnosis to molecular pathways and treatment options; current and future.

引用

页数：17

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