In Vivo Imaging of Mineral Deposition in Carotid Plaque Using 18F-Sodium Fluoride PET/CT: Correlation with Atherogenic Risk Factors

被引:145
作者
Derlin, Thorsten [1 ]
Wisotzki, Christian [1 ]
Richter, Ulrich [2 ]
Apostolova, Ivayla [3 ]
Bannas, Peter [4 ]
Weber, Christoph [4 ]
Mester, Janos [1 ]
Klutmann, Susanne [1 ]
机构
[1] Univ Med Ctr Hamburg Eppendorf, Dept Nucl Med, Hamburg, Germany
[2] Univ Med Ctr Hamburg Eppendorf, Dept Anat Expt Morphol 2, Hamburg, Germany
[3] Charite, Dept Nucl Med, D-13353 Berlin, Germany
[4] Univ Med Ctr Hamburg Eppendorf, Dept Diagnost & Intervent Radiol, Hamburg, Germany
关键词
F-18-sodium fluoride; plaque; atherosclerosis; calcification; carotid; cardiovascular risk factors; PET/CT; POSITRON-EMISSION-TOMOGRAPHY; VASCULAR CALCIFICATION; ATHEROSCLEROTIC PLAQUE; F-18-FDG PET/CT; INFLAMMATION; STROKE; DISEASE; FEASIBILITY; EXPRESSION; ARTERIES;
D O I
10.2967/jnumed.110.081208
中图分类号
R8 [特种医学]; R445 [影像诊断学];
学科分类号
1002 ; 100207 ; 1009 ;
摘要
The purpose of this study was to correlate F-18-sodium fluoride accumulation in the common carotid arteries of neurologically asymptomatic patients with cardiovascular risk factors and carotid calcified plaque burden. Methods: Two hundred sixty-nine oncologic patients were examined by F-18-sodium fluoride PET/CT. Tracer accumulation in the common carotid arteries was analyzed both qualitatively and semiquantitatively by measuring the blood-pool-corrected standardized uptake value (target-to-background ratio) and comparing it with cardiovascular risk factors and calcified plaque burden. Results: F-18-sodium fluoride uptake was observed at 141 sites in 94 (34.9%) patients. Radiotracer accumulation was colocalized with calcification in all atherosclerotic lesions. F-18-sodium fluoride uptake was significantly associated with age (P < 0.0001), male sex (P < 0.0001), hypertension (P < 0.002), and hypercholesterolemia (P < 0.05). The presence of calcified plaque correlated significantly with these risk factors but also with diabetes (P < 0.0001), history of smoking (P = 0.03), and prior cardiovascular events (P < 0.01). There was a highly significant correlation between the presence of F-18-sodium fluoride uptake and number of present cardiovascular risk factors (r = 0.30, P < 0.0001). Conclusion: Carotid F-18-sodium fluoride uptake is a surrogate measure of calcifying carotid plaque, correlates with cardiovascular risk factors, and is more frequent in patients with a high-risk profile for atherothrombotic events but demonstrates a weaker correlation with risk factors than does calcified plaque burden. This study provides a rationale to conduct further prospective studies to determine whether F-18-sodium fluoride uptake can predict vascular events, or if it may be used to monitor pharmacologic therapy.
引用
收藏
页码:362 / 368
页数:7
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