Use of Whole-Genome Sequencing in the Investigation of a Nosocomial Influenza Virus Outbreak

被引：46

作者：

Houlihan, Catherine F. ^{[1
]}

Frampton, Dan ^{[1
]}

Ferns, R. Bridget ^{[1
,4
]}

Raffle, Jade ^{[1
]}

Grant, Paul ^{[5
]}

Reidy, Myriam ^{[6
]}

Hail, Leila ^{[6
]}

Thomson, Kirsty ^{[7
]}

Mattes, Frank ^{[5
]}

Kozlakidis, Zisis ^{[1
,8
]}

Pillay, Deenan ^{[1
]}

Hayward, Andrew ^{[2
,8
]}

Nastouli, Eleni ^{[3
,5
]}

机构：

[1] UCL, Great Ormond St Inst Child Hlth, Div Infect & Immun, London, England

[2] UCL, Great Ormond St Inst Child Hlth, Inst Epidemiol & Hlth Care, London, England

[3] UCL, Great Ormond St Inst Child Hlth, Dept Populat Policy & Practice, London, England

[4] UCL Hosp Natl Hlth Serv Fdn Trust, Natl Inst Hlth Res, Biomed Res Ctr, London, England

[5] UCL Hosp Natl Hlth Serv Fdn Trust, Dept Clin Virol, London, England

[6] UCL Hosp Natl Hlth Serv Fdn Trust, Infect Control Serv, London, England

[7] UCL Hosp Natl Hlth Serv Fdn Trust, Dept Blood Dis, London, England

[8] Farr Inst Hlth Informat Res, Dept Infect Dis Informat, London, England

来源：

JOURNAL OF INFECTIOUS DISEASES | 2018年 / 218卷 / 09期

基金：

英国惠康基金;

关键词：

Influenza; nosocomial; sequencing; transmission; A(H1N1)PDM09; CANADA;

D O I：

10.1093/infdis/jiy335

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Traditional epidemiological investigation of nosocomial transmission of influenza involves the identification of patients who have the same influenza virus type and who have overlapped in time and place. This method may misidentify transmission where it has not occurred or miss transmission when it has. We used influenza virus whole-genome sequencing (WGS) to investigate an outbreak of influenza A virus infection in a hematology/oncology ward and identified 2 separate introductions, one of which resulted in 5 additional infections and 79 bed-days lost. Results from WGS are becoming rapidly available and may supplement traditional infection control procedures in the investigation and management of nosocomial outbreaks.

引用

页码：1485 / 1489

页数：5

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