High expression of neuroguidin increases the sensitivity of acute myeloid leukemia cells to chemotherapeutic drugs

被引：2

作者：

Chen, Kejun ^{[1
]}

Lu, Shuqing ^{[1
]}

Cheng, Hui ^{[1
]}

Tang, Gusheng ^{[1
]}

Liu, Min ^{[1
]}

Zhou, Hong ^{[1
]}

Wang, Jianmin ^{[1
]}

机构：

[1] Second Mil Med Univ, Changhai Hosp, Dept Hematol, Shanghai 200433, Peoples R China

来源：

JOURNAL OF HEMATOLOGY & ONCOLOGY | 2015年 / 8卷

基金：

中国国家自然科学基金;

关键词：

Neuroguidin; Acute myeloid leukemia; Multidrug-resistant; Chemotherapeutic drug; mTOR; INITIATION-FACTOR; 4E; BINDING-PROTEIN; CANCER; EIF4E; SURVIVAL; RAPAMYCIN; 4E-BP1;

D O I：

10.1186/s13045-015-0108-6

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Neuroguidin (NGDN) is a eukaryotic translation initiation factor 4E binding protein. The purpose of this study was to clarify the function of NGDN and its possible mechanism of action in human myeloid leukemia cells. Proliferation inhibition and apoptosis in NGDN over-expressing myeloid multidrug-resistant leukemia cells (K562/A02-NGDN) was significantly higher than in control K562/A02 cells following treatment with vincristine, etoposide, and epirubicin, indicating that NGDN over-expression can increase the sensitivity of multidrug-resistant leukemia cells to chemotherapeutic drugs. Furthermore, NGDN knock-down in K562/A02 cells resulted in the activation of multiple tumor-related signaling pathways, especially the mammalian target of rapamycin (mTOR) pathway.

引用

页数：4

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