Controlled Release of Doxorubicin for Targeted Chemo-Photothermal Therapy in Breast Cancer HS578T Cells Using Albumin Modified Hybrid Nanocarriers

被引：11

作者：

Carrese, Barbara ^{[1
]}

Cavallini, Chiara ^{[2
]}

Sanita, Gennaro ^{[3
]}

Armanetti, Paolo ^{[2
]}

Silvestri, Brigida ^{[4
]}

Cali, Gaetano ^{[5
]}

Pota, Giulio ^{[4
]}

Luciani, Giuseppina ^{[4
]}

Menichetti, Luca ^{[2
]}

Lamberti, Annalisa ^{[1
]}

机构：

[1] Univ Naples Federico II, Dept Mol Med & Med Biotechnol, I-80131 Naples, Italy

[2] CNR, Inst Clin Physiol, I-56124 Pisa, Italy

[3] CNR, Inst Appl Sci & Intelligent Syst, I-80078 Naples, Italy

[4] Univ Naples Federico II, Dept Chem Mat & Prod Engn, I-80125 Naples, Italy

[5] CNR, Inst Endocrinol & Expt Oncol, I-80131 Naples, Italy

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2021年 / 22卷 / 20期

关键词：

doxorubicin; photothermal; breast cancer; PTT; hybrid nanoparticles; melanin nanoparticles; drug delivery; MELANIN NANOPARTICLES; DELIVERY;

D O I：

10.3390/ijms222011228

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Hybrid nanomaterials have attracted research interest owing to their intriguing properties, which may offer new diagnostic options with triggering features, able to realize a new kind of tunable nanotherapeutics. Hybrid silica/melanin nanoparticles (NPs) containing silver seeds (Me-laSil_Ag-HSA NPs) disclosed relevant photoacoustic contrast for molecular imaging. In this study we explored therapeutic function in the same nanoplatform. For this purpose, MelaSil_Ag-HSA were loaded with doxorubicin (DOX) (MelaSil_Ag-HSA@DOX) and tested to assess the efficiency of drug delivery combined with concurrent photothermal treatment. The excellent photothermal properties allowed enhanced cytotoxic activity at significantly lower doses than neat chemotherapeutic treatment. The results revealed that MelaSil_Ag-HSA@DOX is a promising platform for an integrated photothermal (PT) chemotherapy approach, reducing the efficacy concentration of the DOX and, thus, potentially limiting the several adverse side effects of the drug in in vivo treatments.

引用

页数：14

共 27 条

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