A siege of hepatitis Immune boost for viral hepatitis

被引：18

作者：

Callendret, Benoit ^{[1
]}

Walker, Christopher ^{[1
]}

机构：

[1] Ohio State Univ, Ctr Vaccines & Immun, Nationwide Childrens Hosp, Columbus, OH 43210 USA

来源：

NATURE MEDICINE | 2011年 / 17卷 / 03期

关键词：

T-CELLS; C VIRUS; INFECTION; BLOCKADE; LIVER;

D O I：

10.1038/nm0311-252

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Finding mechanisms of viral resistance and new ways to tackle chronic hepatitis will help find a cure for this disease. In 'Bench to Bedside', Christopher Walker and Benoit Callendret highlight studies showing that overcoming immune exhaustion during chronic infection by blocking several inhibitory pathways of T cells may restore an adequate immune response. In 'Bedside to Bench', Lawrence Corey, Joshua Schiffer and John Scott discuss recent advances in antiviral therapy with protease inhibitors and the findings of a mathematical model that predicts possible single and double mutations prior to antiviral therapy.

引用

页码：252 / 253

页数：2

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