Cytotoxic Picrotoxane-type Sesquiterpenoid Lactones from Dendrobium huoshanense

被引：5

作者：

Chen, Xiaoxiao ^{[1
,4
]}

Hu, Jiaomiao ^{[2
]}

Wu, Siyu ^{[1
]}

Zhao, Hongsu ^{[1
]}

Peng, Daiyin ^{[1
]}

Wu, Deling ^{[1
,3
]}

Xu, Fengqing ^{[1
,3
]}

机构：

[1] Anhui Univ Chinese Med, Hefei 230012, Peoples R China

[2] Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resource West Chi, Kunming 650201, Yunnan, Peoples R China

[3] Anhui Prov Key Lab Res & Dev Chinese Med, Hefei 230012, Peoples R China

[4] Luan City Hosp Tradit Chinese Med, Luan 237000, Peoples R China

来源：

RECORDS OF NATURAL PRODUCTS | 2022年 / 16卷 / 02期

关键词：

Dendrobium huoshanense; picrotoxane-type sesquiterpene; cytotoxicity; CHEMICAL-CONSTITUENTS;

D O I：

10.25135/rnp.260.21.04.2048

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Bioassay-guided led to the isolation of five compounds, including a new picrotoxane-type sesquiterpene lactone, aduncin C (1), together with four known ones (2-5) from Dendrobium huoshanense. Their structures were elucidated by means of extensive spectroscopic analysis. Biological evaluation of the isolates against four human cancer cell lines indicated broad-spectrum and cytotoxic activities with IC50 values ranging from 4.08 to 26.75 mu M. Among them, alpha-dihydropicrotoxinin (3) exhibited significant cell proliferation inhibitory activity, especially for HL-60 (IC50 5.81 mu M), MCF- 7 (IC50 6.49 mu M), SW-480 (IC50 6.80 mu M), respectively.

引用

页码：144 / 149

页数：6

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