A review of anti-tumour effects of ginsenoside in gastrointestinal cancer

被引:22
作者
Xu, Jing [1 ]
Pan, Yunxia [1 ]
Liu, Yanyan [2 ,3 ,4 ]
Na, Sha [2 ,3 ,4 ]
Zhou, Hui [2 ,3 ,4 ]
Li, Lu [2 ,3 ,4 ]
Chen, Fengyuan [1 ,3 ,4 ]
Song, Hang [1 ,2 ,3 ,4 ]
机构
[1] Anhui Univ Chinese Med, Sch Integrated Tradit Chinese & Western Med, Hefei, Peoples R China
[2] Anhui Univ Chinese Med, Sch Integrated Tradit Chinese & Western Med, Dept Biochem & Mol Biol, Hefei, Peoples R China
[3] Anhui Acad Chinese Med, Inst Integrat Med, Hefei, Peoples R China
[4] Key Lab Chinese Med Formula Anhui Prov, Hefei, Peoples R China
关键词
ginsenoside; gastrointestinal cancer; autophagy; apoptosis; natural product; EPITHELIAL-MESENCHYMAL TRANSITION; COLORECTAL TUMOR-GROWTH; GASTRIC-CANCER; INHIBITS PROLIFERATION; 20(S)-GINSENOSIDE RG3; ANTICANCER ACTIVITY; DOWN-REGULATION; RED GINSENG; COMPOUND K; CELL-DEATH;
D O I
10.1093/jpp/rgab048
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Objectives: Gastrointestinal cancer, one of the major causes of cancer-related deaths in the world, refers to malignant conditions of the gastrointestinal (GI) tract and other organs. Although conventional therapy has been successful to some extent in cancer treatment, drug resistance and cancer recurrence still limit the therapeutic efficacy. There is increasing evidence indicating that ginsenoside, as a kind of high nutritional value and widely used traditional Chinese medicine, could contribute to the promotion of treatment in GI cancer, which deserves further investigation. Key findings: Based on previous studies, the possible mechanisms mainly include regulation of autophagy, apoptosis, proliferation, migration and angiogenesis. However, no studies recently have conducted a more in-depth review of the anti-cancer effects of ginsenoside in GI cancer. Summary: Therefore, this review will summarise and analyse the latest developments in the anti-tumour effects of ginsenosides in GI cancer, thus may promote further research of the anti-tumour efficacy of ginsenoside.
引用
收藏
页码:1292 / 1301
页数:10
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