A review of inflammation and fibrosis: implications for the pathogenesis of Peyronie's disease

被引：42
作者：
Patel, Darshan P. [1 ]
Christensen, Michael B. [1 ]
Hotaling, James M. [1 ]
Pastuszak, Alexander W. [1 ]
机构：
[1] Univ Utah, Div Urol, Dept Surg, Ctr Reconstruct Urol & Mens Hlth,Sch Med, 30 N 1900 E,Rm 3B420, Salt Lake City, UT 84132 USA
来源：
WORLD JOURNAL OF UROLOGY | 2020年 / 38卷 / 02期
关键词：
Peyronie's disease; Penile induration; Dupuytren's contracture; Ledderhose disease; Fibrosis; Inflammation; Transforming growth factor beta; Cytokines; GROWTH-FACTOR-BETA; TGF-BETA; GENE-EXPRESSION; MATRIX METALLOPROTEINASES; MOLECULAR-MECHANISMS; SIGNAL-TRANSDUCTION; DUPUYTRENS-DISEASE; ASSOCIATION; TISSUE; PATHOPHYSIOLOGY;
D O I：
10.1007/s00345-019-02815-6
中图分类号：
R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];
学科分类号：
1002 ; 100201 ;
摘要：
Peyronie's disease (PD) is a superficial fibrosing disorder that causes penile deformity and can interfere with sexual intercourse and reproduction, as well as diminish quality of life. While the exact mechanism of PD is still being investigated, there is likely a genetic component to the predisposition to penile plaque formation. Ultimately, however, perturbations in normal wound healing and aberrant deposition of extracellular matrix components lead to fibrotic tissue deposition. Fibrosis in PD is regulated by a complex pathway of inflammatory and fibrotic mediators. Currently there are no treatments for PD that address an underlying cause or disease progression. In this review, we provide an overview of the known inflammatory and fibrotic mediators of PD and explore the pathophysiology of other human superficial fibrosing disorders to develop further insights into PD.
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收藏
页码：253 / 261
页数：9
相关论文
共 73 条
[1]   Erectile dysfunction and Peyronie's disease in patient with retroperitoenal fibrosis [J].
Akbal, Cem ;
Tanidir, Yiloeren ;
Ozgen, Mahir Bulent ;
Simsek, Ferruh .
INTERNATIONAL UROLOGY AND NEPHROLOGY, 2008, 40 (04) :971-975
[2]   COMPARATIVE EFFECTS OF GROWTH-FACTORS ON FIBROBLASTS OF DUPUYTRENS TISSUE AND NORMAL PALMAR FASCIA [J].
ALIOTO, RJ ;
ROSIER, RN ;
BURTON, RI ;
PUZAS, JE .
JOURNAL OF HAND SURGERY-AMERICAN VOLUME, 1994, 19A (03) :442-452
[3]   NOX4/NADPH oxidase expression is increased in pulmonary fibroblasts from patients with idiopathic pulmonary fibrosis and mediates TGFβ1-induced fibroblast differentiation into myofibroblasts [J].
Amara, Nadia ;
Goven, Delphine ;
Prost, Fabienne ;
Muloway, Rachel ;
Crestani, Bruno ;
Boczkowski, Jorge .
THORAX, 2010, 65 (08) :733-738
[4]   The role of transforming growth factor beta in Dupuytren's disease [J].
Badalamente, MA ;
Sampson, SP ;
Hurst, LC ;
Dowd, A ;
Miyasaka, K .
JOURNAL OF HAND SURGERY-AMERICAN VOLUME, 1996, 21A (02) :210-215
[5]   PLATELET-DERIVED GROWTH-FACTOR IN DUPUYTRENS DISEASE [J].
BADALAMENTE, MA ;
HURST, LC ;
GRANDIA, SK ;
SAMPSON, SP .
JOURNAL OF HAND SURGERY-AMERICAN VOLUME, 1992, 17A (02) :317-323
[6]   Genetic susceptibility in Dupuytren's disease:: Lack of association of a novel transforming growth factor β2 polymorphism in Dupuytren's disease [J].
Bayat, A ;
Alansar, A ;
Hajeer, AH ;
Shah, M ;
Watson, JS ;
Stanley, JK ;
Ferguson, MWJ ;
Ollier, WER .
JOURNAL OF HAND SURGERY-BRITISH AND EUROPEAN VOLUME, 2002, 27B (01) :47-49
[7]  
Berndt A, 1995, HISTOCHEM J, V27, P1014
[8]   β-catenin is a central mediator of pro-fibrotic Wnt signaling in systemic sclerosis [J].
Beyer, Christian ;
Schramm, Amelie ;
Akhmetshina, Alfiya ;
Dees, Clara ;
Kireva, Trayana ;
Gelse, Kolja ;
Sonnylal, Sonali ;
de Crombrugghe, Benoit ;
Taketo, Makoto Mark ;
Distler, Oliver ;
Schett, Georg ;
Distler, Joerg H. W. .
ANNALS OF THE RHEUMATIC DISEASES, 2012, 71 (05) :761-767
[9]  
Bilgutay Aylin N, 2015, Curr Sex Health Rep, V7, P117
[10]   Implications of nitric oxide synthase isoforms in the pathophysiology of Peyronie's disease [J].
Bivalacqua, TJ ;
Champion, HC ;
Hellstrom, WJG .
INTERNATIONAL JOURNAL OF IMPOTENCE RESEARCH, 2002, 14 (05) :345-352
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