Magnetic Amine-Functionalized UiO-66 for Oxaliplatin Delivery to Colon Cancer Cells: In Vitro Studies

被引：22

作者：

Hashemzadeh, Alireza ^{[1
,2
,3
]}

Amerizadeh, Forouzan ^{[3
,4
,5
]}

Asgharzadeh, Fereshteh ^{[1
]}

Drummen, Gregor P. C. ^{[6
]}

Hassanian, Seyed Mahdi ^{[3
]}

Landarani, Mohammad ^{[7
]}

Avan, Amir ^{[3
,4
]}

Sabouri, Zahra ^{[8
]}

Darroudi, Majid ^{[5
,9
]}

Khazaei, Majid ^{[1
,3
]}

机构：

[1] Mashhad Univ Med Sci, Dept Med Physiol, Fac Med, Mashhad, Razavi Khorasan, Iran

[2] Mashhad Univ Med Sci, Dept Med Biotechnol, Fac Med, Mashhad, Razavi Khorasan, Iran

[3] Mashhad Univ Med Sci, Metab Syndrome Res Ctr, Mashhad, Razavi Khorasan, Iran

[4] Mashhad Univ Med Sci, Fac Med, Dept Med Genet, Mashhad, Razavi Khorasan, Iran

[5] Mashhad Univ Med Sci, Sch Med, Fac Med, Dept Med Biotechnol & Nanotechnol, Mashhad, Razavi Khorasan, Iran

[6] Bio&Nano Solut LAB3BIO, Bio Nanotechnol & Hepato Renal Pathobiol Programs, Bielefeld, Germany

[7] Shahid Beheshti Univ, Fac Chem, Tehran 1983963113, Iran

[8] Mashhad Univ Med Sci, Appl Biomed Res Ctr, Mashhad, Razavi Khorasan, Iran

[9] Mashhad Univ Med Sci, Nucl Med Res Ctr, Mashhad, Razavi Khorasan, Iran

来源：

JOURNAL OF CLUSTER SCIENCE | 2022年 / 33卷 / 05期

基金：

美国国家科学基金会;

关键词：

The metal-organic framework (MOF); Colorectal cancer (CRC); Drug delivery; Cytotoxicity; Magnetic nanoparticle; METAL-ORGANIC FRAMEWORKS; COLORECTAL-CANCER; ELECTRONIC-STRUCTURE; DRUG-DELIVERY; NANOPARTICLES; CISPLATIN; TOXICITY; STABILITY; EFFICACY; THERAPY;

D O I：

10.1007/s10876-021-02158-6

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

UiO-66-NH2 (U) and its magnetic UiO-66-NH2 form (MU) were used to enhance Oxaliplatin (OX) efficacy. The fundamental physical and structural properties of nanoparticles were characterized via X-ray Diffraction (XRD), Fourier Transform Infrared (FTIR), UV-Visible (UV-Vis), Brunauer-Emmett-Teller (BET) surface area analysis, field emission scanning electron microscopy (FESEM), Energy-dispersive X-ray analysis (EDAX) and mapping, and Dynamic light scattering (DLS). The results further showed an improved anticancer activity and efficacy of the designed drug delivery systems (DDSs) compared to OX in 2-and 3-dimensional models of colorectal cancer in which cell viability, proliferation and migration, and morphology were assessed. Additionally, the oxidative/antioxidant activity of U and MU-loaded OX demonstrated greater oxidative behavior compared to OX. In vitro experiments showed that U and MU could inhibit the proliferation and migration of colorectal cancer cells in a dose-dependent manner. The half-maximal inhibitory concentration (IC50) values were found to be 6.10 ppm for OX, 18.47 ppm for MU(OX), and 47.02 ppm for U(OX), respectively. The U(OX) and MU(OX) were more effective than OX in terms of drug release. The results indicate that U and MU show considerable promise as a novel and effective drug delivery system for the treatment of colorectal cancer and possibly other malignancies.

引用

页码：2345 / 2361

页数：17

共 76 条

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