Inducible nitric oxide synthase inhibition by mycophenolic acid

被引：0
作者：
Miljkovic, D
Markovic, M
Trajkovic, V
机构：
[1] Inst Biol Res, Dept Neurobiol & Immunol, Belgrade, Serbia Monteneg, Serbia
[2] Sch Med, Inst Microbiol & Immunol, Belgrade, Serbia Monteneg, Serbia
来源：
MINI-REVIEWS IN MEDICINAL CHEMISTRY | 2004年 / 4卷 / 07期
关键词：
mycophenolic acid; mycophenolate mofetil; nitric oxide; iNOS;
D O I：
暂无
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
The focus of this review is the influence of an immunosuppressive xenobiotic drug mycophenolic acid on the induction of nitric oxide production in various cell types. The potential therapeutic significance of the cell-specific fine-tuning of nitric oxide release by mycophenolic acid, as well as the mechanisms behind the drug action are discussed.
引用
收藏
页码：741 / 746
页数：6
相关论文
共 63 条
[1]  
ALLISON AC, 1993, SPRINGER SEMIN IMMUN, V14, P353
[2]  
ALLISON AC, 1991, TRANSPL P, V23, P10
[3]   Mycophenolate mofetil and its mechanisms of action [J].
Allison, AC ;
Eugui, EM .
IMMUNOPHARMACOLOGY, 2000, 47 (2-3) :85-118
[4]  
Amin Ashok R., 1999, Current Opinion in Rheumatology, V11, P202, DOI 10.1097/00002281-199905000-00009
[5]   Alterations of endothelial nucleotide levels by mycophenolic acid result in changes of membrane glycosylation and E-selectin expression [J].
Bertalanffy, P ;
Dubsky, P ;
Wolner, E ;
Weigel, G .
CLINICAL CHEMISTRY AND LABORATORY MEDICINE, 1999, 37 (03) :259-264
[6]   PASSIVE-IMMUNIZATION AGAINST CACHECTIN TUMOR NECROSIS FACTOR PROTECTS MICE FROM LETHAL EFFECT OF ENDOTOXIN [J].
BEUTLER, B ;
MILSARK, IW ;
CERAMI, AC .
SCIENCE, 1985, 229 (4716) :869-871
[7]  
Bhat NR, 1998, J NEUROSCI, V18, P1633
[8]   Inhibition of endothelial receptor expression and of T-cell ligand activity by mycophenolate mofetil [J].
Blaheta, RA ;
Leckel, K ;
Wittig, B ;
Zenker, D ;
Oppermann, E ;
Harder, S ;
Scholz, M ;
Weber, S ;
Schuldes, H ;
Encke, A ;
Markus, BH .
TRANSPLANT IMMUNOLOGY, 1998, 6 (04) :251-259
[9]   Mycophenolate mofetil impairs transendothelial migration of allogeneic CD4 and CD8 T-cells [J].
Blaheta, RA ;
Leckel, K ;
Wittig, B ;
Zenker, D ;
Oppermann, E ;
Harder, S ;
Scholz, M ;
Weber, S ;
Encke, A ;
Markus, BH .
TRANSPLANTATION PROCEEDINGS, 1999, 31 (1-2) :1250-1252
[10]   Mycophenolate mofetil decreases endothelial prostaglandin E2 in response to allogeneic T cells or cytokines [J].
Blaheta, RA ;
Nelson, K ;
Oppermann, E ;
Leckel, K ;
Harder, S ;
Cinatl, J ;
Weber, S ;
Shipkova, M ;
Encke, A ;
Markus, BH .
TRANSPLANTATION, 2000, 69 (09) :1977-1981
1234567