Hapten Design, Modification and Preparation of Artificial Antigens

被引：59

作者：

Song Juan ^{[1
]}

Wang Rong-Mei ^{[1
]}

Wang Yue-Qiu ^{[1
]}

Tang Yu-Rong ^{[1
]}

Deng An-Ping ^{[1
]}

机构：

[1] Sichuan Univ, Coll Chem, Chengdu 610064, Peoples R China

来源：

CHINESE JOURNAL OF ANALYTICAL CHEMISTRY | 2010年 / 38卷 / 08期

基金：

中国国家自然科学基金;

关键词：

Hapten; Artificial antigens; Design; Modification; Immunoassay; Review; LINKED-IMMUNOSORBENT-ASSAY; SOLID-PHASE EXTRACTION; S-TRIAZINE HERBICIDES; ENZYME-IMMUNOASSAY; MALACHITE GREEN; ELISA; ANTIBODIES; SPECIFICITY; SENSITIVITY; WATER;

D O I：

10.1016/S1872-2040(09)60063-3

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

The key step to develop an immunoassay for small molecular compound is to synthesize artificial antigens with good immunogenicity. In this article, the hapten design and modification (e.g. the choice of modified sites, preparation of hapten derivative, choice of linking spacer), selection of carrier, coupling of hapten derivative to carrier (including coupling method, coupling conditions, the best coupling rate), purification and identification of artificial antigens were reviewed.

引用

页码：1211 / 1218

页数：8

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