Advances of podophyllotoxin and its derivatives: Patterns and mechanisms

被引：27
作者：
Shi, Rong-jia [1 ,2 ,3 ]
Fan, Hua-yang [1 ,2 ,3 ]
Yu, Xiang-hua [1 ,2 ,4 ]
Tang, Ya-ling [1 ,2 ,4 ]
Jiang, Jian [5 ]
Liang, Xin-hua [1 ,2 ,3 ]
机构：
[1] Sichuan Univ, State Key Lab Oral Dis, West China Hosp Stomatol, 14 Sec 3,Renminnan Rd, Chengdu 610041, Sichuan, Peoples R China
[2] Sichuan Univ, Natl Clin Res Ctr Oral Dis, West China Hosp Stomatol, 14 Sec 3,Renminnan Rd, Chengdu 610041, Sichuan, Peoples R China
[3] Sichuan Univ, Dept Oral & Maxillofacial Surg, West China Hosp Stomatol, 14 Sec 3,Renminnan Rd, Chengdu 610041, Sichuan, Peoples R China
[4] Sichuan Univ, Dept Oral Pathol, West China Hosp Stomatol, 14 Sec 3,Renminnan Rd, Chengdu 610041, Sichuan, Peoples R China
[5] Univ Elect Sci & Technol China, Sichuan Canc Hosp & Inst, Sichuan Canc Ctr, Sch Med,Dept Head & Neck Surg, Chengdu 610041, Sichuan, Peoples R China
来源：
BIOCHEMICAL PHARMACOLOGY | 2022年 / 200卷
基金：
中国国家自然科学基金; 美国国家科学基金会;
关键词：
Podophyllotoxin; Anticancer; Anti-inflammatory; Immunosuppression; Antivirals; Codelivery nano-drug systems; CELL LUNG-CANCER; CO-DELIVERY; ETOPOSIDE; THERAPY; GROWTH; DEATH; NANOPARTICLES; PROLIFERATION; ANGIOGENESIS; NECROPTOSIS;
D O I：
10.1016/j.bcp.2022.115039
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Podophyllotoxin (PPT) has attracted researchers' attention because of its ability to treat various ailments. A series of podophyllotoxin derivatives (PPTs) have been synthesized as candidate drugs to improve the pharmacological characteristics of PPT. Nowadays, an increasing number of reviews have summarized structure-optimization, anticancer application, and single nano delivery of PPT and PPTs. In this review, we focus on the multidirectional pharmacological properties of PPT and PPTs, with an emphasis on the crosstalk with anticancer, anti-inflammatory, immunosuppression, and antivirals. Besides, the newly uncovered mechanisms governing PPT and PPTs in anticancer property including non-apoptotic regulated cell death are discussed. Moreover, their co-delivery nanocarriers with other antitumor drugs or biological agents that have the potential to achieve increased targeting efficacy are included. We hope that a better comprehension of this subject will help to provide a reference for improving the druggability and expanding the clinical application of podophyllotoxin and its derivatives.
引用
收藏
页数：10
相关论文
共 123 条
[1]   Combinatory Delivery of Etoposide and siCD47 in a Lipid Polymer Hybrid Delays Lung Tumor Growth in an Experimental Melanoma Lung Metastatic Model [J].
Abdel-Bar, Hend Mohamed ;
Walters, Adam A. ;
Wang, Julie Tzu-Wen ;
Al-Jamal, Khuloud T. .
ADVANCED HEALTHCARE MATERIALS, 2021, 10 (07)
[2]   Virtual screening-driven repositioning of etoposide as cd44 antagonist in breast cancer cells [J].
Aguirre-Alvarado, Charmina ;
Segura-Cabrera, Aldo ;
Velazquez-Quesada, Ines ;
Hernandez-Esquivel, Miguel A. ;
Garcia-Perez, Carlos A. ;
Guerrero-Rodriguez, Sandra L. ;
Ruiz-Moreno, Angel J. ;
Rodriguez-Moreno, Andrea ;
Perez-Tapia, Sonia M. ;
Velasco-Velazquez, Marco A. .
ONCOTARGET, 2016, 7 (17) :23772-23784
[3]   Distinct Characteristics and Clinical Outcomes to Predict the Emergence of MET Amplification in Patients with Non-Small Cell Lung Cancer Who Developed Resistance after Treatment with Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors [J].
Ahn, Beung-Chul ;
Lee, Ji Hyun ;
Kim, Min Hwan ;
Pyo, Kyoung-Ho ;
Lee, Choong-kun ;
Lim, Sun Min ;
Kim, Hye Ryun ;
Cho, Byoung Chul ;
Hong, Min Hee .
CANCERS, 2021, 13 (12)
[4]   Hemophagocytic Lymphohistiocytosis [J].
Al-Samkari, Hanny ;
Berliner, Nancy .
ANNUAL REVIEW OF PATHOLOGY: MECHANISMS OF DISEASE, VOL 13, 2018, 13 :27-49
[5]   Case Report: Successful Treatment of Five Critically Ill Coronavirus Disease 2019 Patients Using Combination Therapy With Etoposide and Corticosteroids [J].
Aoyagi, Tetsuji ;
Sato, Yukio ;
Baba, Hiroaki ;
Shiga, Takuya ;
Seike, Issei ;
Sugaya, Ikumi Niitsuma ;
Takei, Kentarou ;
Iwasaki, Yudai ;
Oshima, Kengo ;
Kanamori, Hajime ;
Yoshida, Makiko ;
Saito, Koji ;
Tokuda, Koichi ;
Kaku, Mitsuo .
FRONTIERS IN MEDICINE, 2021, 8
[6]   ETOPOSIDE AND CORTICOSTEROID COMBINATION THERAPY IMPROVES ACUTE RESPIRATORY DISTRESS SYNDROME IN MICE [J].
Aoyagi, Tetsuji ;
Sato, Yukio ;
Toyama, Masahiko ;
Oshima, Kengo ;
Kawakami, Kazuyoshi ;
Kaku, Mistuo .
SHOCK, 2019, 52 (01) :83-91
[7]   Dissecting Programmed Cell Death with Small Molecules [J].
Bai, Yingjie ;
Lam, Hiu C. ;
Lei, Xiaoguang .
ACCOUNTS OF CHEMICAL RESEARCH, 2020, 53 (05) :1034-1045
[8]  
Baldwin E. L., 2005, Current Medicinal Chemistry - Anti-Cancer Agents, V5, P363, DOI 10.2174/1568011054222364
[9]   Confirmed efficacy of etoposide and dexamethasone in HLH treatment: long-term results of the cooperative HLH-2004 study [J].
Bergsten, Elisabet ;
Horne, AnnaCarin ;
Arico, Maurizio ;
Astigarraga, Itziar ;
Egeler, R. Maarten ;
Filipovich, Alexandra H. ;
Ishii, Eiichi ;
Janka, Gritta ;
Ladisch, Stephan ;
Lehmberg, Kai ;
McClain, Kenneth L. ;
Minkov, Milen ;
Montgomery, Scott ;
Nanduri, Vasanta ;
Rosso, Diego ;
Henter, Jan-Inge .
BLOOD, 2017, 130 (25) :2728-2738
[10]  
Blair HA, 2018, DRUGS, V78, P1903, DOI 10.1007/s40265-018-1022-3
12345678910