Dimethylarginine dimethylaminohydrolase: A new therapeutic target for the modulation of nitric oxide and angiogenesis

被引：0
作者：
Singh, Jai Pal [1 ]
机构：
[1] Eli Lilly & Co, Lilly Corp Ctr, Indianapolis, IN 46286 USA
来源：
CURRENT OPINION IN INVESTIGATIONAL DRUGS | 2007年 / 8卷 / 09期
关键词：
angiogenesis; asymmetric dimethylarginine; dimethylarginine dimethylaminohydrolase; nitric oxide; progenitor cell;
D O I：
暂无
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Nitric oxide ( NO) has a key role in promoting angiogenesis by increasing vasodilation, vascular permeability, endothelial cell proliferation and migration, and by modifying the activities of angiogenic mediators. NO is also critical for the mobilization of endothelial progenitor cells from the bone marrow which promotes vasculogenesis and angiogenesis. Studies have shown that the enzymes catalyzing NO synthesis are inhibited by the endogenously generated inhibitor asymmetric dimethylarginine ( ADMA). Pharmacological agents targeted to modulate dimethylarginine dimethylaminohydrolase, the key enzyme metabolizing ADMA, may offer a potential strategy for developing novel pro-and anti-angiogenic therapies.
引用
收藏
页码：736 / 741
页数：6
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