Human spinal arachnoid villi revisited: immunohistological study and review of the literature

被引:24
作者
Tubbs, R. Shane
Hansasuta, Ake
Stetler, William
Kelly, David R.
Blevins, Danitra
Humphrey, Rrra
Chua, Gina D.
Shoja, Mohammadali M.
Loukas, Marios
Oakes, W. Jerry
机构
[1] Univ Alabama, Sect Pediat Neurosurg, Birmingham, AL USA
[2] Univ Alabama, Dept Cell Biol, Birmingham, AL 35294 USA
[3] Univ Alabama, Sch Med, Birmingham, AL USA
[4] Ramathibodi Hosp, Div Neurosurg, Bangkok, Thailand
[5] Tabriz Univ, Tuberculosis & Lung Dis Inst, Tabriz, Iran
[6] St Georges Univ, Dept Anat Sci, St Georges, Grenada
[7] Harvard Univ, Sch Med, Dept Educ & Dev, Boston, MA USA
关键词
absorption; anatomy; cerebrospinal fluid; spine;
D O I
10.3171/SPI-07/09/328
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Object. Few have described the relationship between arachnoid protrusions (villi) and adjacent spinal radicular veins, and the descriptions that do exist are conflicting. Some authors have even denied the presence of spinal arachnoid villi, suggesting that they play no role in cerebrospinal fluid (CSF) absorption. Methods. To further elucidate these structures, laminectomies from C-2 inferiorly to S-2 were performed in 10 fresh human adult cadavers. Following removal of the laminae, the dural nerve sleeves were identified and the spinal nerves excised 1 cm lateral and medial to the intervertebral foramina. Samples were submitted for histological and immunohistological analysis. Results. The authors identified arachnoid villi in all specimens. The length of these structures was approximately 50 to 170 mu m. Regionally, these villi were more concentrated in the lumbar region, but they were not present at every vertebral level, with observed skip zones. Occasionally, more than one villus was identified per vertebral level. The majority of villi were intimately related to an adjacent radicular vein. There was a direct relationship between the size of the adjacent radicular vein, and the presence and number of arachnoid villi. Conclusions. Findings in the present study have demonstrated that arachnoid villi exist and are morphologically associated with radicular veins. These data support the theory that CSF absorption occurs not only intracranially but also along the spinal axis. Further animal studies are necessary to prove that CSF traverses these villi and is absorbed into the spinal venous system.
引用
收藏
页码:328 / 331
页数:4
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