Expanding the Chemical Space of Nonribosomal Peptide Synthetase-like Enzymes by Domain and Tailoring Enzyme Recombination

被引：8
作者：
van Dijk, Johannes W. A. [1 ]
Wang, Clay C. C. [1 ,2 ]
机构：
[1] Univ Southern Calif, Sch Pharm, Dept Pharmacol & Pharmaceut Sci, Los Angeles, CA 90089 USA
[2] Univ Southern Calif, Dept Chem, Coll Letters Arts & Sci, Los Angeles, CA 90089 USA
来源：
ORGANIC LETTERS | 2018年 / 20卷 / 17期
基金：
美国国家科学基金会;
关键词：
SECONDARY METABOLITES; HETEROLOGOUS EXPRESSION; GENES; ASPERGILLUS; OXIDATION; SYSTEM;
D O I：
10.1021/acs.orglett.8b01581
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The potential of tailoring enzymes in combination with engineered hybrid nonribosomal peptide synthetase-like enzymes was explored and resulted in methylated and prenylated forms of novel natural products, highlighting the possibilities and limitations of this approach.
引用
收藏
页码：5082 / 5085
页数：4
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