Efficient syntheses of imidazolo[1,2-a]pyridines and -[2,1-a]isoquinolines

被引：41

作者：

Katritzky, AR ^{[1
]}

Qiu, GF

Long, QH

He, HY

Steel, PJ

机构：

[1] Univ Florida, Dept Chem, Ctr Heterocycl Cpds, Gainesville, FL 32611 USA

[2] Univ Canterbury, Dept Chem, Christchurch 1, New Zealand

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2000年 / 65卷 / 26期

关键词：

D O I：

10.1021/jo0012602

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

8-Aminopyridines la-e and 1-aminoisoquinoline with 1-chloromethylbenzotriazole give 2-amino-1-[alpha -benzotriazol-1-ylmethyl]pyridinium chlorides 2a-c and 1-amino-2-(alpha -benzotriazol-1-ylmethyl)isoquinolinium chloride 12, respectively. Compounds 2a-c and 12 react with aryl aldehydes 3a-h to afford imidazolo [1,2-a]pyridines 7a-k and imidazolo[2,1-a] isoquinolines 13a,b in good yields.

引用

页码：9201 / 9205

页数：5

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