MicroRNA-378 enhances inhibitory effect of curcumin on glioblastoma

被引：39

作者：

Li, Wende ^{[1
,2
,5
]}

Yang, Weining ^{[3
,4
]}

Liu, Yujiao ^{[2
]}

Chen, Siyu ^{[5
]}

Chin, Shanmin ^{[2
]}

Qi, Xiaolong ^{[2
]}

Zhao, Yingchao ^{[6
]}

Liu, Hao ^{[2
]}

Wang, Jiasheng ^{[1
]}

Mei, Xueting ^{[1
]}

Huang, Peigen ^{[2
]}

Xu, Donghui ^{[1
]}

机构：

[1] Sun Yat Sen Univ, Sch Life Sci, Lab Tradit Chinese Med & Marine Drugs, Guangzhou 510275, Guangdong, Peoples R China

[2] Harvard Med Sch, Massachusetts Gen Hosp, Edwin L Steele Lab, Boston, MA 02114 USA

[3] Univ Toronto, Sunnybrook Hlth Sci Ctr, Toronto, ON, Canada

[4] Univ Toronto, Dept Lab Med & Pathobiol, Toronto, ON, Canada

[5] Guangdong Lab Anim Monitoring Inst, Guangdong Key Lab Lab Anim, Guangzhou 510663, Guangdong, Peoples R China

[6] Huazhong Univ Sci & Technol, Union Hosp, Tongji Med Coll, Canc Ctr, Wuhan 430022, Hubei, Peoples R China

来源：

ONCOTARGET | 2017年 / 8卷 / 43期

关键词：

miR-378; glioblastoma; U87; curcumin; CANCER-CELL-LINES; BREAST-CANCER; SIGNALING PATHWAYS; MALIGNANT GLIOMAS; DRUG-RESISTANCE; LUNG-CANCER; IN-VITRO; EXPRESSION; SUPPRESSES; KINASE;

D O I：

10.18632/oncotarget.17881

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Glioblastoma multiforme is the most aggressive and common primary brain tumor, and is virtually incurable due to its therapeutic resistance to radiation and chemotherapy. Curcumin is a well-known phytochemical exhibiting antitumor activity on many human cancers including glioblastoma multiforme. Given the unique miRNA expression profiles in cancer cells compared to non-cancerous cells, we investigated whether these miRNA could be used to cancer therapy. In this report we show that miR-378, a glioblastoma multiforme down regulated miRNA, may enhance the inhibitory effect of curcumin on this cancer growth. Our results indicated that the inhibitory effect of curcumin was enhanced in miR-378-expressing stable U87 cells in vitro and in vivo, compared to control cells. MiR-378 was found to target p-p38 expression, underlying the observed phenotypic changes. Thus, we concluded that miR-378 enhances the response of glioblastoma multiforme to curcumin treatment, by targeting p38.

引用

页码：73938 / 73946

页数：9