Carica papaya increases regulatory T cells and reduces IFN-γ+CD4+ T cells in healthy human subjects

被引：15

作者：

Abdullah, Maha ^{[1
]}

Chai, Pei-Shin ^{[1
]}

Loh, Chiew-Yee ^{[1
]}

Chong, Mun-Yee ^{[1
]}

Quay, Huai-Wei ^{[1
]}

Vidyadaran, Sharmili ^{[1
]}

Seman, Zainina

Kandiah, Mirnalini

Seow, Heng-Fong ^{[1
]}

机构：

[1] Univ Putra Malaysia, Fac Med & Hlth Sci, Dept Pathol, Immunol Unit, Serdang 43400, Selangor, Malaysia

来源：

MOLECULAR NUTRITION & FOOD RESEARCH | 2011年 / 55卷 / 05期

关键词：

Carica papaya; Cytokines; Immunoregulation; Inflammation; Regulatory T cells; CONSUMPTION; INFLAMMATION; EXPRESSION; FRUIT;

D O I：

10.1002/mnfr.201100087

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

Fruit and vegetables have therapeutic potential as they dampen inflammation, have no known side-effects and as whole foods have prospective additive and synergistic benefits. Th1 (IFN-gamma(+)CD4(+))/Th2 (IL-4(+)CD4(+)) T cells play a vital role in mediating inflammatory responses and may be regulated by regulatory T cells (Tregs). Effects of Carica papaya on cells of healthy individuals were determined using flow cytometry methods. Significant down-regulation of IFN-gamma(+)CD4(+) (p = 0.03, n = 13), up-regulation of IL-4(+)CD4(+) (p = 0.04, n = 13) T cells and up-regulation of CD3(+)CD4(+)CD25(+)CD127(-) (p = 0.001, n = 15) Tregs were observed after papaya consumption. In vitro cultures showed up-regulation of Tregs in male subjects and was significantly associated with levels of IL-1 beta in culture supernatants (R-2 = 0.608, p = 0.04, n = 12). Other inflammatory cytokines were significantly suppressed. Papaya consumption may exert an anti-inflammatory response mediated through Tregs and have potential in alleviating inflammatory conditions.

引用

页码：803 / 806

页数：4

共 23 条

[1] CD4+CD25high regulatory cells in human peripheral blood [J].