A BAT-Centric Approach to the Treatment of Diabetes: Turn on the Brain

被引：35
作者：
Hankir, Mohammed K. [1 ]
Cowley, Michael A. [2 ]
Fenske, Wiebke K. [1 ]
机构：
[1] Univ Leipzig, Dept Med, Integrated Res & Treatment Ctr Adipos Dis, D-04103 Leipzig, Saxony, Germany
[2] Monash Univ, Monash Obes & Diabet Inst, Dept Physiol, Clayton, Vic 3800, Australia
来源：
CELL METABOLISM | 2016年 / 24卷 / 01期
基金：
英国医学研究理事会;
关键词：
BROWN ADIPOSE-TISSUE; REGULATES GLUCOSE-HOMEOSTASIS; SYMPATHETIC-NERVE ACTIVITY; MELANOCORTIN; 4; RECEPTORS; INSULIN-SENSITIVITY; POMC NEURONS; AGRP NEURONS; BEIGE FAT; IN-VIVO; COLD-EXPOSURE;
D O I：
10.1016/j.cmet.2016.05.003
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The marked (18)F-flurodeoxyglucose uptake by brown adipose tissue ( BAT) enabled its identification in human positron emission tomography imaging studies. In this Perspective, we discuss how glucose extraction by BAT and beige adipose tissue (BeAT) sufficiently impacts on glycemic control. We then present a unique overview of the central circuits modulated by gluco-regulatory hormones, temperature, and glucose itself, which converge on sympathetic preganglionic neurons and whose activation syphon circulating glucose into BAT/BeAT. Targeted stimulation of the sympathetic nervous system at specific nodes to selectively recruit BAT/BeAT may represent a safe and effective means of treating diabetes.
引用
收藏
页码：31 / 40
页数：10
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