Four new microginins, linear peptides from the cyanobacterium Microcystis aeruginosa

被引：38
作者：
Ishida, K [1 ]
Matsuda, H [1 ]
Murakami, M [1 ]
机构：
[1] Univ Tokyo, Grad Sch Agr & Life Sci, Marine Biochem Lab, Bunkyo Ku, Tokyo 113, Japan
来源：
TETRAHEDRON | 1998年 / 54卷 / 44期
关键词：
D O I：
10.1016/S0040-4020(98)00826-6
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Four new linear peptides, related to microginins 299-A (1) and 299-B (2), were isolated from the cyanobacterium Microcystis aeruginosa. Microginins 299-C (3) and 299-D (4), from M. aeruginosa (NIES-299), inhibited leucine aminopeptidase with IC50's of 2.0 and 6.4 mu g/mL, respectively. Microginins 99-A (5) and 99-B (6), from M. aeruginosa (NIES-99), did not inhibit leucine aminopeptidase. These structures were elucidated to be 3-6 on the basis of 2D NMR data and chemical degradation. (C) 1998 Elsevier Science Ltd. All rights reserved.
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页码：13475 / 13484
页数：10
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