Construction of the 0D/2D heterojunction of Ti3C2Tx MXene nanosheets and iron phthalocyanine quantum dots for the impedimetric aptasensing of microRNA-155

被引：78
作者：
Duan, Fenghe [1 ,2 ]
Guo, Chuanpan [1 ,2 ]
Hu, Mengyao [1 ]
Song, Yingpan [1 ]
Wang, Minghua [1 ]
He, Linghao [1 ]
Zhang, Zhihong [1 ]
Pettinari, Riccardo [2 ]
Zhou, Liming [1 ]
机构：
[1] Zhengzhou Univ Light Ind, Henan Prov Key Lab Surface & Interface Sci, Zhengzhou 450002, Peoples R China
[2] Univ Camerino, Chem & Pharmaceut Sci & Biotechnol Chem Sci, Via S Agostino 1, I-62032 Camerino, MC, Italy
来源：
SENSORS AND ACTUATORS B-CHEMICAL | 2020年 / 310卷
基金：
中国国家自然科学基金;
关键词：
Ti3C2Tx MXene nanosheets; Iron phthalocyanine; Nanohybrid; Electrochemical aptasensor; Detection of miRNA-155; Impedimetric aptasensing; ULTRASENSITIVE ELECTROCHEMICAL DETECTION; RAMAN-SPECTROSCOPY PLATFORM; FIELD-EFFECT TRANSISTOR; SIGNAL AMPLIFICATION; SILVER NANOPARTICLES; ZINC PHTHALOCYANINE; COPPER NANOCLUSTERS; ORGANIC FRAMEWORKS; BIOSENSOR; PERFORMANCE;
D O I：
10.1016/j.snb.2020.127844
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
A promising nanocarrier of the complementary DNA (cDNA) toward miRNA-155 was synthesized on the basis of the nanohybrid type of Ti3C2Tx MXene nanosheets decorated using iron phthalocyanine quantum dots (FePc QDs) (denoted as Ti3C2Tx@FePcQDs) to construct a novel ultrasensitive impedimetric aptasensing system for microRNA-155 (miRNA-155). Owing to pi-pi* stacking interaction between Ti3C2Tx nanosheets and FePc QDs, the homogeneous nanostructure of the Ti3C2Tx@FePcQD nanohybrid that comprises mixed-valence states (Ti2+/Ti-3(+) and Fe2+/Fe3+), multicomponent (Ti-O and Ti-C), and various N-related groups was achieved. The constructed Ti3C2Tx@FePcQDs-based aptasensor displayed an ultrahigh sensitivity for detecting miRNA-155 with a low detection limit of 4.3 aM (S/N = 3) within the miRNA-155 concentration ranging from 0.01 fM to 10 pM. Compared with the individual component-based aptasensors and other reported miRNA-155 aptasensors, the proposed impedimetric aptasensing system exhibited substantial merits of a feasible preparation process, nonuse of labels or electrochemical indicators, fast response time, and comprehensive sensing performances for detecting miRNA-155. This strategy for determining miRNAs can extensively be applied as the platform for anchoring other kinds of aptamers in detecting diverse targets, thus indicating its great potential application for the early diagnosis of cancer biomarkers.
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页数：11
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